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US 2007/0185314 A1Published application
Crystals of LuxP and complexes thereof
OwnerBonnie Bassler, Stephan Schauder +3inventors
InventorsBonnie Bassler, Stephan Schauder, Xin Chen, Frederick Hughson, Stephen Cooper
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Abstract
A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
Claims14
A crystal comprising LuxP.
14-17. (canceled)
Dependencies are inferred from the claim text.