Crystal forms of cinacalcet HCI and processes for their preparation
AssigneeTeva Pharmaceutical Industries Ltd.
InventorsShlomit Wizel, Revital Lifshitz-Liron, Sharon Avhar-Maydan
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Abstract
Provided are crystalline forms of cinacalcet HCl and processes for their preparation.
Claims45
A chloroform solvate of Cinacalcet HCl.
A crystalline form of Cinacalcet HCl, characterized by a powder XRD pattern, having four x-ray powder diffraction peaks selected from the following:
- about 10.6°, 13.9°, 16.4°, 17.1° and 21.6°±0.2° 2θ.
A crystalline form of Cinacalcet HCl, characterized by a powder XRD pattern, having four x-ray powder diffraction peaks selected from the following:
- about 13.8, 17.7°, 19.6°, 20.4° and 23.5°±0.2° 2θ.
A process for the preparation of Cinacalcet HCl Form I, comprising heating a crystalline form of Cinacalcet HCl characterized by a powder XRD pattern, having four x-ray powder diffraction peaks selected from the following:
- about 13.8, 17.7°, 19.6°, 20.4° and 23.5°±0.2° 2θ.
A pharmaceutical composition, comprising the Cinacalcet HCl Form II or III and at least one pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.