Medicinal compositions containing 6-hydroxybenzbromarone or salts thereof
AssigneeHuman Cell Systems, Inc.
InventorsHitoshi Endou, Toshihiro Oikawa
Life of this patent
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Abstract
[PROBLEMS] To provide highly safe therapeutic or preventive agents for hyperuricemia, more specifically uricosuric agents, which have potent uricosuric effect and do not cause grave hepatic disorder. [MEANS FOR SOLVING PROBLEMS] Medicinal compositions for the treatment or prevention of hyperuricemia or diseases caused by hyperuricemia, which contain 6-hydroxybenzbromarone or salts thereof, and pharmaceutically acceptable carriers; uricosuric agents, xanthine oxidase inhibitors, and inhibitors against the uptake of uric acid in kidney, which contain 6-hydroxybenzbromarone or salts thereof; and a process for the production of 6-hydroxybenzbromarone.
Claims18
A medical composition containing 6-hydroxybenzbromarone or salt thereof, and a pharmaceutically acceptable carrier.
An inhibitor for inhibiting the uptake or uric acid in kidney containing 6-hydroxybenzbromarone or sale thereof.
8-9. (canceled)
A method for manufacturing 6-hydroxybenzbromarone comprising brominating 2-ethyl-6-hydroxy-3-(p-hydroxy-benzoyl)-benzofuran (hydroxy group thereof may be protected as necessary using a brominating agent and then deprotecting a protective group of a hydroxy group.
A method for treating a subject suffering from or susceptible to hyperuricemia or a disorder resulting therefrom, comprising:
- administering to the subject an effective amount of 6-hydroxybenzbromarone or salt thereof.
Dependencies are inferred from the claim text.