Prolinylarylacetamides

Compounds of the formula I

• in which
• R denotes Hal, —C≡C—H, —C≡C-A or OA,
• R1 denotes H, ═O, Hal, A, OH, OA, A-COO—, Ph-(CH2)n—COO—, cycloalkyl-(CH2)n—COO—, A-CONH—, A-CONA-, Ph-CONA-, N3, NH2, NO2, CN, COOH, COOA, CONH2, CONHA, CON(A)2, O-allyl, O-propargyl, O-benzyl, ═N—OH, ═N—OA or ═CF2,
• X, X′ each, independently of one another, denote CH, CHal or N,
• Y denotes R4 or Hal,
• Ph denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by A, OA, OH or Hal,
• R2 denotes H, Hal or A,
• R3 denotes H or A,
• R4 denotes OH, OA, A-COO—, NHA, NHAr, NAA′, Het or —NH—CHR5—COOR,
• R5 denotes H, A, —CHR3—OH, (CH2)n-Ph, (CH2)n—COOH, (CH2)n—CONH2, (CH2)p—NH2, (CH2)n—NH(═NH)NH2, (CH2)n-Het1 or (CH2)n—SR3,
• Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by A, OH, OA, CN, COOH, COOA and/or carbonyl oxygen (═O),
• Het1 denotes a mono- or bicyclic aromatic heterocycle having 1 to 4 N, O and/or S atoms, which may be unsubstituted or mono-, di- or trisubstituted by A, OH, OA and/or CN,
• A, A′ each, independently of one another, denote unbranched, branched or cyclic alkyl having 1-12 C atoms, in which, in addition, 1-7 H atoms may be replaced by F and/or chlorine,
• Ar denotes naphthyl, biphenyl, or phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, OR3, N(R3)2, NO2, CN, COOR3, CON(R3)2, NR3COA, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, S(O)nA, —[C(R3)2]n—COOR3 or —O—[C(R3)2]p—COOR3,
• Hal denotes F, Cl, Br or I,
• n denotes 0, 1, 2 or 3,
• p denotes 1, 2, 3, 4 or 5,
• and pharmaceutically usable derivatives, solvates, salts and stereoisomers thereof, including mixtures thereof in all ratios.