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US 2007/0185186 A1Published application
Compositions for the delivery of substituted napthyl indole derivatives and methods of their use
AssigneeWyeth
InventorsBehnam Abdolalizadeh, T. Armstrong, James Provost, Zerina Shafi, M. Ku
Life of this patent
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Abstract
This invention relates to compositions for the delivery of substituted naphthyl indole derivatives as well as to the use of these compositions and methods for treating disease.
Claims23
A composition comprising:
- about 1% to about 90% by weight of an active ingredient of Formula I:
- wherein:
- R1, R2, R3, and R4 are each, independently, hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3-5 carbon atoms, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-6 carbons, halogen, hydroxy, aryl optionally substituted with from 1 to 3 groups selected from R8, perfluoroalkyl of 1-6 carbons, alkoxy of 1-6 carbons, amino, alkylamino of 1-6 carbons, dialkylamino of 1-6 carbons, or perfluoroalkoxy of 1-6 carbons;
- R5 is hydrogen, alkyl of 1-6 carbons, perfluoroalkyl of 1-6 carbons, aryl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
- R6 is hydrogen, alkyl of 1-6 carbons, alkylaryl, benzyl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
- R7 is hydrogen, alkyl of 1-6 carbons, alkylaryl, or aryl optionally substituted with from 1 to 3 groups selected from R8;
- n is an integer of 0-6;
- A is COOH, or an acid mimic;
- and
- R8 is hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3-5 carbons, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-6 carbons, halogen, hydroxy, perfluoroalkyl of 1-6 carbons, alkoxy of 1-6 carbons, amino, alkylamino of 1-6 carbons, dialkylamino of 1-6 carbons, or perfluoroalkoxy of 1-6 carbons,
- or a pharmaceutically acceptable salt or ester form thereof;
- and
- about 0.1% to about 10% by weight of a surfactant.
10 more elements
A process comprising mixing a compound of Formula I:
- wherein:
- R1, R2, R3, and R4 are each, independently, hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3-5 carbon atoms, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-6 carbons, halogen, hydroxy, aryl optionally substituted with from 1 to 3 groups selected from R8, perfluoroalkyl of 1-6 carbons, alkoxy of 1-6 carbons, amino, alkylamino of 1-6 carbons, dialkylamino of 1-6 carbons, or perfluoroalkoxy of 1-6 carbons;
- R5 is hydrogen, alkyl of 1-6 carbons, perfluoroalkyl of 1-6 carbons, aryl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
- R6 is hydrogen, alkyl of 1-6 carbons, alkylaryl, benzyl substituted with R8, alkanoyl of 1-6 carbons, or aroyl optionally substituted with from 1 to 3 groups selected from R8;
- R7 is hydrogen, alkyl of 1-6 carbons, alkylaryl, or aryl optionally substituted with from 1 to 3 groups selected from R8;
- n is an integer of 0-6;
- A is COOH, or an acid mimic;
- and
- R8 is hydrogen, alkyl of 1-6 carbons, cycloalkyl of 3-5 carbons, —CH2-cycloalkyl of 3-5 carbon atoms, alkanoyl of 1-6 carbons, halogen, hydroxy, perfluoroalkyl of 1-6 carbons, alkoxy of 1-6 carbons, amino, alkylamino of 1-6 carbons, dialkylamino of 1-6 carbons, or perfluoroalkoxy of 1-6 carbons,
- or a pharmaceutically acceptable salt or ester form thereof;
- with at least one surfactant;
- at least one disintegrant;
- and at least one glidant thereby forming a mixture blend thereof.
10 more elements
Dependencies are inferred from the claim text.