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US 2007/0185183 A1Published application
Indolinesulphanilic acid amides as ppar-delta modulators
AssigneeBayer HealthCare LLC
InventorsStephan Siegel, Michael Woltering, Elke Dittrich-Wengenroth
Life of this patent
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Abstract
The invention relates to novel indolin-sulfanilic acid amides of general formula (I), methods for the production thereof, and the use thereof in medicaments, especially as potent PPAR delta agonists for preventing and/or treating cardiovascular diseases, particularly dyslipidemia, arteriosclerosis, and coronary heart diseases.
Claims13
A compound of formula (I)
- in which
- R1 represents phenyl or represents 5- or 6-membered heteroaryl having up to two heteroatoms from the group consisting of N, O and S, which radicals may for their part each be mono- to trisubstituted by identical or different substituents selected from the group consisting of halogen, cyano, nitro, (C1-C6)-alkyl (which for its part may be substituted by hydroxyl), (C1-C6)-alkoxy, trifluoromethyl, trifluoromethoxy, (C1-C6)-alkylsulphonyl, (C1-C6)-alkanoyl, (C1-C6)-alkoxycarbonyl, carboxyl, amino, (C1-C6)-acylamino, mono- and di-(C1-C6)-alkylamino,
- R2 and R3 are identical or different and independently of one another represent hydrogen or (C1-C4)-alkyl or together with the carbon atom to which they are attached form a 3- to 7-membered spiro-linked cycloalkyl ring,
- R4 represents hydrogen or (C1-C4)-alkyl,
- R5 represents hydrogen, (C1-C4)-alkyl, (C1-C4)-alkoxy or halogen,
- R6 represents (C1-C6)-alkyl, (C3-C8)-cycloalkyl, (C1-C6)-alkanoyl, (C1-C6)-alkylsulphonyl or (C1-C6)-alkoxycarbonyl,
- R7 and R8 are identical or different and independently of one another represent hydrogen or (C1-C4)-alkyl,
- and
- R9 represents hydrogen or a hydrolyzable group which can be degraded to the corresponding carboxylic acid,
- or a pharmaceutically acceptable salt thereof.
7 more elements
A compound of formula (I-A)
- in which
- R1 represents phenyl which is substituted by fluorine, chlorine or trifluoromethyl,
- and
- R6 represents methyl, ethyl, n-propyl, isopropyl or tert-butyl.
1 more element
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.