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US 2007/0185182 A1Published application
Heteroaryl carboxamide compounds
AssigneeHoffmann-La Roche Inc.
InventorsAurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
Life of this patent
Estimating the term…
Abstract
Compounds of formula I their manufacture, pharmaceutical compositions containing them and their use as medicaments.
Claims16
A compound of formula I
- wherein
- —X—Y— is —CRa═CRc— or —CRa═N— or —CRaRb—CRcRd—,
- wherein Ra, Rb, Rc and Rd are independently from each other selected from the group consisting of hydrogen and C1-C8alkyl;
- R1, R2, R4 and R5 are independently from each other selected from the group consisting of hydrogen, C1-C8alkyl, C1-C8alkoxy, halogen and halogen-C1-C8alkyl;
- R3 is Si(C1-C6alkyl)3;
- R6 is selected from the group consisting of hydrogen and C1-C8alkyl;
- R7 is selected from the group consisting of hydrogen, C1-C8alkyl, hydroxy and halogen;
- R8 is selected from the group consisting of C1-C8alkyl, C2-C8alkenyl, halogen-C1-C8alkyl, heterocyclyl, heteroaryl which is unsubstituted or substituted by one or two groups independently selected from C1-C8alkyl, C1-C8alkoxy, halogen-C1-C8alkyl, halogen-C1-C8alkoxy and halogen, phenyl which is unsubstituted or substituted by one or two groups independently selected from C1-C8alkyl, C1-C8alkoxy, halogen-C1-C8alkyl, halogen-C1-C8alkoxy and halogen, —OR12, wherein R12 is C1-C8alkyl or phenyl which is unsubstituted or substituted by one or two groups independently selected from C1-C8alkyl, C1-C8alkoxy, halogen-C1-C8alkyl, halogen-C1-C8alkoxy and halogen, —NR13R14, wherein R13 and R14 independently from each other are selected from hydrogen, C1-C8alkyl, and phenyl which is unsubstituted or substituted by one or two groups independently selected from C1-C8alkyl, C1-C8alkoxy, halogen-C1-C8alkyl, halogen-C1-C8alkoxy and halogen, and —C(O)—OR5, wherein R5 is hydrogen or C1-C8alkyl;
- R9, R10 and R11 independently from each other are selected from the group consisting of hydrogen, C1-C8alkyl, cycloalkyl, C1-C8alkoxy, halogen-C1-C8alkyl, and halogen;
- n is 1, 2 or 3;
- and all pharmaceutically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.