Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors

A compound of Formula (II)

• an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein:
• R1 is hydrogen, halo, amino, substituted amino, alkyl, substituted alkyl, cycloalkyl, aryl or heterocyclo;
• R2 is hydrogen, halo, cyano, C1-C4 alkyl or C3-C6 cycloalkyl;
• each of G, X and Y is independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH;
• and
• B is independently selected from:
• wherein
• R3 is hydrogen, halo, cyano, optionally substituted C1-C4 alkyl, optionally substituted C3-C6 cycloalkyl, amino or substituted amino;
• R4 is hydrogen, amino, substituted amino, alkyl, substituted alkyl, cycloalkyl, cyano, aryl or heterocyclo;
• R5 is hydrogen, amino, substituted amino, alkyl, substituted alkyl, cycloalkyl, cyano, or heterocyclo;
• R8 is hydrogen, cyano, alkyl, substituted alkyl, cycloalkyl or heterocyclo;
• R9 is hydrogen, alkyl or substituted alkyl;
• and
• Z is O, S or NR10, wherein R10 is hydrogen, alkyl, substituted alkyl, cycloalkyl, aryl, substituted aryl or heterocyclo.

A process for preparing a compound of Formula (III):

• comprising the step of reacting a compound of Formula (IV):
• with R11 NCS and a base, wherein:
• each of G, X and Y is independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH;
• R11 is alkyl, substituted alkyl, cycloalkyl, aryl, heterocyclo or trimethylsylyl;
• D is a leaving group;
• and
• Q is hydrogen, halo, cyano, nitro, RS—, substituted amino, alkyl, substituted alkyl, cycloalkyl, heterocyclic, aryl, heteroaryl, —CO2R, —COR or —CONR2,
• wherein each R is independently alkyl, aryl, arylalkyl, heterocyclo, heteroaryl, heteroarylalkyl, cycloheteroalkyl, cycloheteroalkylalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl or thioalkyl,
• further wherein each R in —CONR2 may be taken together with N to form 1-pyrrolidinyl, 1-piperidinyl, 1-azepinyl, 4-morpholinyl, 4-thiamorpholinyl, 1-piperazinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl, 4-diarylalkyl-1-piperazinyl, 1-pyrrolidinyl, 1-piperidinyl or 1-azepinyl, optionally substituted with alkyl, aryl, heterocyclo, alkoxy, alkylthio, halo, trifluoromethyl, hydroxy, amino, —C(O)Rf, —C(═O)ORf, —C(═O)NRfRg, —S(O)2Rf, —S(O)2ORf, or —S(O)2NRfRg, wherein Rf and Rg are independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl or heterocyclo.