Compounds and methods of use

A compound of Formula I

• wherein R is selected from unsubstituted or substituted
• 6-10 membered aryl,
• 4-6 membered cycloalkyl,
• 5-6 membered heterocyclyl and
• 9-11 membered bicyclic and 11-14 membered tricyclic heterocyclyl,
• wherein substituted R is substituted with one or more substitutents independently selected from halo, C1-6-alkyl, optionally substituted C3-6-cycloalkyl, optionally substituted phenyl, optionally substituted phenyl-C1-C4-alkylenyl, C1-2-haloalkoxy, optionally substituted phenyloxy, optionally substituted 4-6 membered heterocyclyl-C1-C6-alkyl, optionally substituted 4-6 membered heterocyclyl-C2-C4-alkenyl, optionally substituted 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyloxy, optionally substituted 4-6 membered heterocyclyl-C1-4-alkoxy, optionally substituted 4-6 membered heterocyclylsulfonyl, optionally substituted 4-6 membered heterocyclylamino, optionally substituted 4-6 membered heterocyclylcarbonyl, optionally substituted 4-6 membered heterocyclyl-C1-4-alkylcarbonyl, optionally substituted 4-6 membered heterocyclylcarbonyl-C1-4-alkyl, optionally substituted 4-6 membered heterocyclyl-C1-4-alkylcarbonylamino, optionally substituted 4-6 membered heterocyclyl-oxycarbonylamino, C1-2-haloalkyl, C1-4-aminoalkyl, nitro, amino, C1-3-alkylsulfonylamino, hydroxy, oxo, cyano, aminosulfonyl, C1-2-alkylsulfonyl, halosulfonyl, C1-4-alkylcarbonyl, amino-C1-4-alkylcarbonyl, C1-3-alkylamino-C1-4-alkylcarbonyl, C1-3-alkylamino-C1-4-alkylcarbonylamino, C1-4-alkoxycarbonyl-C1-4-alkyl, C1-3-alkylamino-C1-3-alkyl, C1-3-alkylamino-C1-3-alkoxy, C1-3-alkylamino-C1-3-alkoxy-C1-3-alkoxy, C1-4-alkoxycarbonyl, C1-4-alkoxycarbonylamino-C1-4-alkyl, C1-3-alkylsulfonylamino-C1-3-alkoxy, C1-4-hydroxyalkyl,
• and C1-4-alkoxy;
• wherein R1 is one or more substitutents independently selected from H, halo, hydroxy, amino, C1-6-alkyl, C1-6-haloalkyl, C1-6-alkoxy, C1-2-alkylamino, aminosulfonyl, C3-6-cycloalkyl, cyano, C1-2-hydroxyalkyl, nitro, C2-3-alkenyl, C2-3-alkynyl, C1-6-haloalkoxy, C1-6-carboxyalkyl, 5-6-membered heterocyclyl-C1-6-alkylamino, unsubstituted or substituted phenyl and unsubstituted or substituted 5-6 membered heterocyclyl;
• wherein Ra and Rb are independently selected from H and C1-2-haloalkyl;
• wherein R2 is selected from H, C1-3-alkyl, optionally substituted phenyl, optionally substituted phenyl-C1-3-alkyl, 4-6 membered heterocyclyl, optionally substituted 4-6 membered heterocyclyl-C1-C3-alkyl, C1-3-alkoxy-C1-2-alkyl and C1-3-alkoxy-C1-3-alkoxy-C1-3-alkyl;
• and
• wherein R3 is 7H-pyrrolo[2,3-d]pyrimidine, 1H-pyrrolo[2,3-b]pyridine, 2,3-dihydro-1H-pyrrolo[2,3-b]pyridine or 1H-pyrazolo[3,4-b]pyridine;
• wherein R3 is optionally substituted with oxo, halo, hydroxy, amino, C1-6-alkyl, aminocarbonyl and C1-6-alkoxy;
• and pharmaceutically acceptable derivatives thereof;
• provided R is not 5-trifluoromethyl-2-pyridyl;
• further provided R is not 4,4-dimethyl-1,2,3,4-tetrahydro isoquinolin-7-yl, when R3 is 1H-pyrrolo[2,3-b]pyrid-4-yl or 2,3-dihydro-1H-pyrrolo[2,3-b]pyrid-4-yl.