Derivatives of pyridine and quinoline
AssigneesConsejo Superior de Investigaciones Cientificas, Universidad De Granada
InventorsJuan Carlos Lacal Sanjuan, Joaquin Rosa, Miguel Mezo, Antonio Ubeda
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Abstract
The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors and parasitic diseases or diseases produced by viruses and fungi in animals, including human beings; as well as to a method for preparing the compounds of the invention and certain intermediates of said method.
Claims17
A compound having general formula I:
- where
- Q− represents the conjugate base of a pharmaceutically suitable organic or inorganic acid;
- R1 and R′1 represent, independently of each other, a radical selected from the group formed by H and C1-6 alkyl optionally substituted by trifluoromethyl, hydroxyl or alkoxyl;
- R2 and R′2 represent, independently of each other, an aryl radical optionally substituted by halogen, trifluoromethyl, hydroxyl, C1-6 alkyl, amino or alkoxyl;
- R3 and R′3 represent, independently of each other, either a radical selected from the group formed by H, halogen, trifluoromethyl, hydroxyl, amino, alkoxyl and C1-6 alkyl optionally substituted by trifluoromethyl, hydroxyl, amino or alkoxyl, or together with R4 and R′4 respectively, and independently of each other, a —CH═CH—CH═CH— radical optionally substituted by halogen, trifluoromethyl, hydroxyl, C1-6 alkyl, amino or alkoxyl;
- R4 and R′4 represent, independently of each other, either a radical selected from the group formed by H and C1-6 alkyl optionally substituted by halogen, trifluoromethyl, hydroxyl, amino or alkoxyl, or together with R3 and R′3 respectively, and independently of each other, a —CH═CH—CH═CH— radical optionally substituted by halogen, trifluoromethyl, hydroxyl, C1-6 alkyl, amino or alkoxyl;
- and
- A represents a spacer group.
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Dependencies are inferred from the claim text.