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US 2007/0185163 A1Published application
Imidazol derivatives of piperidine as histamine antagonists
AssigneeAstraZeneca AB
InventorsFraser Hunt, Peter Hamley
Life of this patent
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Abstract
Piperidine compounds according to Formula I wherein R1, m, X, n, p, q, Y, Z and Ar are acs defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy and in the preparation of medicaments.
Claims13
1-8. (canceled)
A compound of formula (IA):
- in which:
- Ar is an aryl group, a 5-7 membered heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, or a bicyclic or tricyclic heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, each of which aryl group or heteroaromatic ring can be optionally substituted by 1-3 groups selected from C1-6 alkyl, C1-6 alkylthio, C1-6 alkoxy, halogen, cyano, CF3, OCF3, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 alkynyl, C2-6-alkenyloxy, hydroxyl, nitro, tosyl, thienyl, benzyl, phenyl, nitrophenyl,
- R1 is hydrogen or C1-6alkyl;
- X is O, NR2, CH2 or SOx
- R2 is C1-6 alkyl;
- x is 0, 1 or 2;
- Y is C═O, SO2, or (C═O)NH;
- Z is (CR3R4)r or Y and Z together form a CH═CH group;
- m and n are independently 0, 1, 2 or 3;
- p and q are independently 0, 1 or 2;
- r is 0, 1, 2, 3, or 4, and
- R3 and R4 are independently hydrogen or C1-6alkyl.
9 more elements
12-15. (canceled)
A method for the treatment of diseases mediated by histamine H3 and H4 receptors
- comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salts or a solvate thereof:
- in which:
- Ar is an aryl group, a 5-7 membered heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, or a bicyclic or tricyclic heteraromatic ring containing 1-4 heteroatoms selected from nitrogen, oxygen or sulphur, each of which aryl group or heteroaromatic ring can be optionally substituted by 1-3 groups selected from C1-6 alkyl, C1-6 alkylthio, C1-6 alkoxy, halogen, cyano, CF3, OCF3, C3-6 cyclolalkyl, C2-6 alkenyl, C1-6 alkynyl, C2-6 alkenyloxy, hydroxyl, nitro, tosyl, thienyl, benzyl, phenyl, nitrophenyl,
- R1 is hydrogen or C1-6 alkyl;
- X is O, NR2, CH2 or SOx
- R2 is C1-6 alkyl;
- x is 0, 1 or 2;
- Y is CH2, C═O, SO2, or (C═O)NH;
- Z is (CR3R4)r or Y and Z together form a CH═CH group;
- m and n are independently 0, 1, 2 or 3;
- p and q are independently 0, 1 or 2;
- r is 0, 1, 2, 3, or 4 and
- R3 and R4 are independently hydrogen or C1-6alkyl.
10 more elements
Dependencies are inferred from the claim text.