1-(2H)-isoquinolone derivative

A compound represented by the following formula (1):

• wherein,
• Y1 and Y4 are independently selected from a hydrogen atom and a halogen atom, either one of Y2 and Y3 represents —NR1R2, and the other represents a hydrogen atom or a halogen atom;
• X represents an aryl group or a heteroaryl group, and the aryl group or heteroaryl group may be substituted with one or more substituents selected from Group A;
• Group A consists of a C1-8 alkyl group (wherein the alkyl group may be substituted with one or more substituents selected from a halogen atom, an aryl group, a heteroaryl group, —OR11, and —NR12R13), a C2-7 alkenyl group (wherein the C2-7 alkenyl group may be substituted with one or more substituents selected from a halogen atom, a C1-8 alkyl group, an aryl C1-6 alkyl group, an aryl group, and a heteroaryl group), a C2-7 alkynyl group (wherein the C2-7 alkynyl group may be substituted with one or more substituents selected from a halogen atom, a C1-8 alkyl group, an aryl C1-6 alkyl group, an aryl group, and a heteroaryl group), a halogen atom, a hydroxyl group, an aryl group, a heteroaryl group, a cyano group, an amino group (wherein the nitrogen atom of the amino group may be substituted with one or two substituents selected from a C1-8 alkyl group, which may be substituted with —OR11 or —NR12R13, an aryl group, an aryl C1-6 alkyl group, and a heteroaryl group), —S(O)nR14 (wherein n represents an integer between 0 and 2), a C1-6 alkoxy group (wherein the alkoxy group may be substituted with one or more groups selected from an aryl group, a heteroaryl group, —OR11, —NR12R13, and a halogen atom), a 4- to 7-membered hetero ring group (wherein the hetero ring group may be substituted with one or more substituents selected from Group D), an aryloxy group, a heteroaryloxy group, and a C1-6 alkylenedioxy group;
• wherein R11, R12, R13, and R14 are independently selected from a hydrogen atom, a C1-8 alkyl group (wherein the alkyl group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group, an amino group, a C1-6 alkylamino group, a di(C1-6 alkyl)amino group, an aryl group, and a heteroaryl group), an aryl group, and a heteroaryl group;
• or R12 and R13, together with nitrogen to which they are bonded, may form a 4- to 7-membered hetero ring containing at least one nitrogen atom;
• R1 represents a hydrogen atom, or a C1-8 alkyl group that may be substituted with one or more substituents selected from Group B;
• R2 represents a C1-8 alkyl group substituted with one or more substituents selected from Group B, —COOR3, —COR4, —COSR5, —CONR6R7, NR22R23, or —N═CR24R25;
• or R1 and R2, together with a nitrogen atom to which they are bonded, may form a 4- to 10-membered hetero ring containing at least one nitrogen atom (wherein the hetero ring may be substituted with one or more substituents selected from Group C);
• wherein
• R3 represents a hydrogen atom, a C1-8 alkyl group, a C2-7 alkenyl group, a C2-7 alkynyl group (wherein the alkyl group, alkenyl group, and alkynyl group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group (wherein the alkoxy group may be substituted with one or more substituents selected from a hydroxyl group, a C1-6 alkoxy group, and a phenyl group), a C3-8 cycloalkyl group, an aryl group, and a heteroaryl group), a C3-8 cycloalkyl group, an aryl group, or a heteroaryl group;
• R4 is selected from a hydrogen atom, a C1-8 alkyl group that may be substituted with one or more R20s , an aryl group, and a heteroaryl group;
• R5 is selected from a hydrogen atom, a C1-8 alkyl group, an aryl group, and a heteroaryl group;
• R20 represents a hydroxyl group, a halogen atom, an aryl group, a heteroaryl group, a C1-6 alkoxy group (wherein the alkoxy group may be substituted with one or more substituents selected from a halogen atom, an aryl group, and a heteroaryl group), an aryloxy group, a heteroaryloxy group, an amino group (wherein the nitrogen atom of the amino group may be substituted with one or two substituents selected from a C1-8 alkyl group, an aryl group, an aryl C1-6 alkyl group, a heteroaryl group, and —COOR21), or a 4- to 7-membered hetero ring group containing at least one nitrogen atom (wherein the hetero ring group may be substituted with a C1-8 alkyl group);
• R21 represents a C1-8 alkyl group, an aryl C1-6 alkyl group, or an aryl group;
• R6 and R7 are independently selected from a hydrogen atom, a C1-8 alkyl group, an aryl group, and a heteroaryl group;
• R22 and R23 are independently selected from a hydrogen atom, a C1-8 alkyl group, an aryl group, and a heteroaryl group;
• R24 and R25 are independently selected from a hydrogen atom, a C1-8 alkyl group, an aryl group, and a heteroaryl group;
• Group B consists of a halogen atom, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a C1-6 alkoxycarbonyl group, an aryl group (wherein the aryl group may be substituted with one or more substituents selected from a halogen atom, a C1-8 alkyl group, a C1-8 haloalkyl group, a hydroxyl group, a C1-6 alkoxy group, and a C1-6 haloalkoxy group), a heteroaryl group, —OR31, and —NR32R33;
• wherein
• R31, R32, and R33 are independently selected from a hydrogen atom, a C1-8 alkyl group (wherein the alkyl group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group, an aryl group, an amino group, a C1-6 alkylamino group, and a di(C1-6 alkyl)amino group), an aryl group, a heteroaryl group, and —COOR34;
• wherein R34 represents a C1-8 alkyl group, an aryl C1-6 alkyl group, or an aryl group;
• or
• R32 and R33, together with a nitrogen atom to which they are bonded, may form a 4- to 7-membered hetero ring containing at least one nitrogen atom (wherein the hetero ring group may be substituted with one or more groups selected from Group D);
• Group C consists of an aryl group, a heteroaryl group, a C1-6 alkylcarbonyl group, a C1-6 alkylaminocarbonyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group, a C1-8 alkyl group, a C1-6 alkoxy group (wherein the alkyl group and alkoxy group may be substituted with one or more substituents selected from a halogen atom, an aryl group, a heteroaryl group, —NR41R42, and —OR43), an aryloxy group, and a heteroaryloxy group;
• wherein
• R41, R42, and R43 are independently selected from a hydrogen atom, a C1-8 alkyl group (wherein the alkyl group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group, an amino group, a C1-6 alkylamino group, and a di(C1-6 alkyl)amino group), an aryl C1-6 alkyl group, an aryl group, and a heteroaryl group;
• or
• R41 and R42, together with a nitrogen atom to which they are bonded, may form a 4- to 7-membered hetero ring containing at least one nitrogen atom;
• and
• Group D consists of a halogen atom, an aryl group, a heteroaryl group, an aryloxy group, a heteroaryloxy group, an amino group (wherein the nitrogen atom of the amino group may be substituted with one or two substituents selected from a C1-8 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy C1-6 alkyl group, a C1-6 alkylamino C1-6 alkyl group, a di(C1-6 alkyl)amino C1-6 alkyl group, an aryl group, an aryl C1-6 alkyl group, and a heteroaryl group), a hydroxyl group, a C1-6 alkoxy group (wherein the alkoxy group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group, a C1-6 alkylamino group, and di(C1-6 alkyl)amino group), a C1-6 alkoxycarbonyl group, a C1-8 alkyl group (wherein the alkyl group may be substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a C1-6 alkoxy group, a C1-6 alkoxycarbonyl group, an amino group, an aryl group, a heteroaryl group, a C1-6 alkylamino group, and a di(C1-6 alkyl)amino group,
• or a prodrug or a pharmaceutically acceptable salt of said compound.