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US 2007/0185158 A1Published application
Indol-4 sulfonamide derivatives, their preparation and their use 5-ht-6 as modulators
AssigneeLaboratorios Del Dr. Esteve, S.A.
InventorsRamon Merce Vidal, Xavier Codony Soler, Alberto Dordal Zueras
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Abstract
The present invention refers to new sulfonamide derivatives, of general formula (1a, 1b, 1c), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemate, or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or their salt thereof s, preferably the corresponding, physiologically acceptable salt thereofs, or corresponding solvate thereofs; to the processes for their preparation, to their application as medicaments in human and/or veterinary therapeutics, and to the pharmaceutical compositions containing them.
Claims72
A sulfonamide compound of general formula (Ia),
- wherein
- R1 represents a —NR8R9 radical or a saturated or unsaturated, optionally at least mono-substituted cycloaliphatic radical, which may contain at least one heteroatom as a ring member and/or which may be condensed with a saturated or unsaturated, optionally at least mono-substituted, optionally at least one heteroatom as a ring member containing mono- or bicyclic cycloaliphatic ring system,
- R2, R3, R5, R6 and R7, identical or different, each represent hydrogen, halogen, nitro, alkoxy, cyano, a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or an optionally at least mono-substituted phenyl or an optionally at least mono-substituted heteroaryl radical,
- R4 is hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical,
- R8 and R9, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical,
- with the proviso that R8 and R9 are not hydrogen at the same time, and if one of them, R8 or R9, is a saturated or unsaturated, linear or branched, optionally at least mono-substituted C1-C4 aliphatic radical, the other one is a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical with at least five carbon atoms, or
- R8 and R9 together with bridging nitrogen atom form a saturated or unsaturated, optionally at least mono-substituted heterocyclic ring, which may contain at least one additional heteroatom as. a ring member and/or may be condensed with a saturated or unsaturated, optionally at least mono-substituted mono- or bicyclic cycloaliphatic ring system, which may optionally contain at least one heteroatom as a ring member,
- A represents an optionally at least mono-substituted mono- or polycyclic aromatic ring system, which may be bonded via an optionally at least mono-substituted alkylene, alkenylene or alkynylene group and/or which may contain at least one heteroatom as a ring member in one or more of its rings, and
- n is 0, 1, 2, 3 or 4;
- optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding, physiologically acceptable salt thereof, or a corresponding solvate thereof.
7 more elements
A sulfonamide compound of general formula (Ib),
- wherein
- R1 represents a —NR8R9 radical,
- R2, R3, R5, R6 and R7, identical or different, each represent hydrogen, halogen, nitro, alkoxy, cyano, a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical, or an optionally at least mono-substituted phenyl or an optionally at least mono-substituted heteroaryl radical,
- R4 is hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted aliphatic radical,
- R8 and R9, identical or different, each represent hydrogen or a saturated or unsaturated, linear or branched, optionally at least mono-substituted C1-4 aliphatic radical,
- A represents an optionally at least mono-substituted mono- or polycyclic aromatic ring system, which may be bonded via an optionally at least mono-substituted alkylene, alkenylene or alkynylene group and/or which may contain at least one heteroatom as a ring member In one or more of its rings, and
- n is 0, 1, 2, 3 or 4;
- optionally in form of one of its stereoisomers, preferably enantiomers or diastereomers, its racemate or in form of a mixture of at least two of its stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or a salt thereof, preferably a corresponding, physiologically acceptable salt thereof, or a corresponding solvate thereof.
5 more elements
Dependencies are inferred from the claim text.