8-Azabicyclo[3.2.1]octane derivatives

A 8-azabicyclo[3.2.1]octane derivative of Formula I,

• wherein
• R1 is H or C1-5alkyl;
• Y is O, S or O(CH2)m;
• m is 1 or 2;
• n is 0 or 1;
• Ar1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar2,said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynlphenyl, CN and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar2 to form a 5-membered ring;
• Ar2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, CN, CONR2R3, CO2R4, NHCOR5 and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar1 to form a 5-membered ring;
• R2-R4 are independently H or C1-5alkyl and
• R5 is C1-5alkyl
• or a pharmaceutically acceptable salt or solvate thereof.