Inhibitors of akt activity

A compound of Formula (I):

• wherein:
• A is selected from:
• nitrogen, —C-halogen and —CH;
• L1 is selected from the group consisting of a bond, —O—, —N(R5)—, —S—, —S(O)—, —S(O2)—, alkyl, and —N(R5)C(O)—;
• L2 is selected from the group consisting of a bond, —O—, heterocycle, —N(R5)—, —N(R5)C(O)—, —S—, —S(O)—, —S(O2)—, and —C(O)N(R5)—;
• L3 is alkyl, wherein the alkyl is optionally substituted with one or two substituents independently selected from the group consisting of amino, methylamino, dimethylamino, oxo, and hydroxy;
• L6 is selected from the group consisting of a bond, —O—, —N(R5)—, —S—, —S(O)—, —S(O2)—, alkyl, and —N(R5)C(O)—;
• R1 is selected from the group consisting of aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycle and substituted heterocycle;
• R2 is selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycle, substituted heterocycle, and a cyclic or polycyclic aromatic ring containing from 3 to 16 carbon atoms and optionally containing one or more heteroatoms, provided that when the number of carbon atoms is 3 the aromatic ring contains at least two heteroatoms and when the number of carbon atoms is 4 the aromatic ring contains at least one heteroatom, and optionally substituted with one or more substituents selected from the group consisting of:
• alkyl, substituted alkyl, trifluoroalkoxy, C1-C12aryl, aryloxy, —O(CH2)qR31, —NHC(O)—NHR41, —C(O)R43, substituted cycloalkyl, substituted C1-C12aryl, heterocycle, substituted heterocycle, oxo, hydroxy, alkoxy, cycloalkyl, acyloxy, amino, N-acylamino, nitro, cyano, halogen, —C(O)OR7, —C(O)NR8R9, —S(O)2NR8R9, and —S(O)nR7,
• where n is 0-2, q is 1-6,
• R7 is hydrogen, alkyl, cycloalkyl, C1-C12aryl, substituted alkyl, substituted cycloalkyl and substituted C1-C12aryl,
• R31 is C1-C12aryl, cycloalkyl and heterocycle, each of which is optionally substituted with from 1 to 4 substituents selected from:
• halogen, alkyl, hydroxyalkyl, alkoxy, acyloxy, amino, methylamino, dimethylamino, N-acylamino, hydroxy, nitro, tetrazole, cyano, oxo and trifluoromethyl,
• R41 is selected from hydrogen, C1-C12aryl, cycloalkyl and heterocycle, wherein C1-C12aryl, cycloalkyl and heterocycle are optionally substituted with from 1 to 4 substituents selected from:
• halogen, alkyl, hydroxyalkyl, alkoxy, amino, methylamino, dimethylamino, hydroxy, nitro, tetrazole, cyano, oxo and trifluoromethyl,
• R43 is selected from C1-C12aryl, cycloalkyl and heterocycle, each of which is optionally substituted with from 1 to 4 substituents selected from:
• halogen, hydroxyalkyl, alkoxy, amino, methylamino, dimethylamino, hydroxy, nitro, tetrazole, cyano, oxo and trifluoromethyl, and
• R8 and R9 are independently hydrogen, cycloalkyl, C1-C12aryl, substituted cycloalkyl, substituted C1-C12aryl, alkyl or alkyl substituted with one or more substituents selected from the group consisting of:
• alkoxy, acyloxy, aryloxy, amino, N-acylamino, oxo, hydroxy, —C(O)OR10, —S(O)nR10, —C(O)NR10R11, —S(O)2NR10R11, nitro, cyano, cycloalkyl, substituted cycloalkyl, halogen, aryl, and substituted aryl,
• or R8 and R9 taken together with the nitrogen to which they are attached represent a 5 to 6 member saturated ring containing up to one other heteroatom selected from oxygen and nitrogen, where the ring is optionally subtituted with one or more substituents selected from amino, methylamino and dimethylamino,
• where R10 and R11 are independently hydrogen, alkyl, cycloalkyl, C1-C12aryl, substituted alkyl, substituted cycloalkyl and substituted C1-C12aryl, and n is 0-2,
• and when L6 is a bond, R2 can additionally be halogen;
• R3 and R6 are independently selected from the group consisting of hydrogen, amino, methylamino, dimethylamino, aryl, substituted aryl, heterocycle, substituted heterocycle, cycloalkyl, substituted cycloalkyl, —S—C1-C12aryl, —O—C1-C12aryl, —OalkylC1-C12aryl, aryloxy, substituted aryloxy and arylalkoxy;
• and
• R4 is selected from the group consisting of hydrogen and halogen;
• where R5 is selected from the group consisting of hydrogen, —S(O)2CH3, —S(O)2H and alkyl;
• provided that when,
• R1 is azaindazole, substituted azaindazole, 1H-thienopyrazole, substituted 1H-thienopyrazole, benzamide, substituted benzamide, phenylethanone, substituted phenylethanone, thiophene, substituted thiophene, furan or substituted furan,
• R2 may additionally be hydrogen;
• further provided that when
• R1 is isoquinoline,
• R2 is not furyl or alkyl.