Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3 and neuronal nicotinic receptor antagonists

A method-of-treating a living animal for alleviation of a condition wherein the compound is selected for its immunomodulatory, anti-malarial, anti-Borna virus, or anti-Hepatitis C, anti-trypanosomal, and anti-HSV efficacy, or for alleviation of a condition treatable by an NMDA, 5HT3 or neuronal nicotinic receptor antagonist comprising the step of administering to the living animal a therapeutically effective amount of a compound selected from those of formula 1,

• wherein
• R and R1 together represent a C3-C5 alkylene or alkenylene group, R2-R5 are each independently selected from hydrogen atoms, C1-C6 alkyl groups, C2-C6 alkenyl groups, C2-C6 alkynyl groups, C6-C12 aryl-C1-C4 alkyl groups, and optionally substituted C6-C12 aryl groups;
• Y is CH;
• and
• Z represents hydrogen atoms attached to Y and N respectively;
• and optical isomers and pharmaceutically-acceptable acid and base addition salts thereof.