M3 muscarinic acetylchoine receptor antagonists

A compound according to Formula I herein below:

• wherein:
• Z1 is, independently, selected from the group consisting of H or C1-6 alkyl;
• R1 is, independently, selected from the group consisting of a substituent selected from:
• Hydrogen, halogen, C1-4 alkyl, —C(O)(C1-6 alkyl), —CO2(C1-6 alkyl), —C(O)(aryl) and —C(O)[(C1-6 alkyl)-aryl];
• G1 is, independently, selected from the group consisting of CH2—CH2 or CH═CH;
• G2 is, independently, selected from the group consisting of C4-7alkyl or a group of the formula (a), (b) or (c):
• R2 is, independently, selected from the group consisting of the formula (d) or (e):
• wherein
• X is, independently, selected from the group consisting of a bond, NR3 or C1-4 alkyl;
• R3 is, independently, selected from the group consisting of H, optionally substituted C1-6 alkyl and C1-4 alkyl-aryl;
• Z is, independently, selected from the group consisting of optionally substituted C1-6 alkyl, C1-6 alkyl-Y2;
• In addition, Z and R3 or Z and Ar may come together to form a 4-7 membered ring;
• Ar is, independently, selected from the group consisting of an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring;
• or an optionally substituted bicyclic or heterobicyclic ring system;
• or an optionally substituted tricyclic or heterotricyclic ring system;
• Ar1 and Ar2 are, independently, selected from a group consisting of an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring;
• Y is, independently, selected from a group consisting of a bond, —NHCO—, —CONH—, —CH2—, and —(CH2)mY1(CH2)n— wherein Y1 represents O, S, SO2, or CO and m and n each represent zero or 1 such that the sum of m+n is zero or 1;
• provided that when R2 represents a group of formula (d) wherein X is a bond, any substituent present in Ar ortho to the carboxamide moiety is necessarily a hydrogen or a methoxy group
• Y2 is, independently, selected from a group consisting of NR3, O, S, —NHC(O)—, —C(O)NH—;
• t is, independently, selected from a group consisting of an integer between 0 and 3.