Sulphonamide derivatives, their preparation and their therapeutic application

A compound having the general formula (I)

• wherein
• Ar1 is either
• an aryl group optionally substituted with one or more substituents independently selected from the group consisting of:
• halogen, a (C1-C4) alkyl group, a (C1-C4) alkoxy group, a fluoro(C1-C4)alkyl group, a cyano group, —CO—NRaRb, and —NRaRb, Ra and Rb being, independently of each other, hydrogen or a (C1-C4) alkyl group;
• or
• a heterocyclyl group selected from pyridyl, pyrimidinyl, thiazolyl and thienyl, said heterocyclyl group being optionally substituted with a halogen, a (C1-C4) alkyl group or a (C1-C4) alkoxy group;
• or
• a (C3-C6) cycloalkyl group;
• T is selected from
• —(CH2)— where n=0, 1 or 2,
• where R2 is a hydroxyl group or a (C1-C4) alkyl group,
• where R3 is a (C1-C4) alkyl group, or
• where R4 is a (C1-C4) alkyl group;
• Ar2 is an aryl group, optionally substituted with one or more substituents independently selected from:
• halogen, C1-C4) alkyl, (C1-C4) alkoxy, fluoro(C1-C4)alkyl, fluoro(C1-C4)alkoxy, and —NRcRd wherein Rc and Rd are, independently of each other, hydrogen or (C1-C4) alkyl, or
• a heterocyclyl group optionally substituted with a (C1-C4) alkyl group or a (C1-C4) alkoxy group;
• Ar3 is an aryl group selected from phenyl and naphthyl, optionally substituted with one or more substituents independently selected from:
• halogen, (C1-C4) alkyl, (C1-C4) alkoxy, fluoro(C1-C4)alkyl, fluoro(C1-C4)alkoxy, nitro, hydroxyl, —NR5R6 where R5 and R6 are, independently of each other, hydrogen or (C1-C4) alkyl, heterocyclyl optionally substituted with (C1-C4) alkyl or (C1-C4) alkoxy, —NRxRy where Rx and Ry are, independently of each other, hydrogen, (C1-C4) alkyl or (C1-C4) alkoxy, or one of the following structures
• R1 is selected from —C(O)—CF3, a group of formula
• in which
• n=0, 1, 2 or 3
• R7 is hydrogen, (C1-C4) alkyl, fluorine or (C1-C4) alkoxy,
• —(CH2)m-aryl, where m=1 or 2 and aryl is a phenyl group optionally substituted with halogen, (C1-C4)
• alkyl or (C1-C4) alkoxy,
• R8 is hydrogen, fluorine or (C1-C4) alkyl, and R9 is hydrogen, (C1-C4) alkyl, hydroxyl, (C3-C6) cycloalkyl, (C1-C4) alkoxy, fluoro(C1-C4)alkyl, —C≡CH, —C≡N, phenoxy, (C1-C4) alkenyl, —NR10R11 where R10 and R11 are, independently of each other, hydrogen, (C1-C4) alkyl, (C1-C4) alkylcarbonyl, (C1-C4) alkylsulfonyl, benzyl or —(CH2)2—N(CH3)2, or, alternatively, R10 and R11, form, together with the nitrogen atom that bears them, a pyrrolidine, a pyrrolidinone, a morpholine or a piperidine,
• —CO—NR12R13 where R12 and R13 are, independently of each other, hydrogen, (C1-C4) alkyl, optionally substituted with a —C≡N group, an aryl group or a heterocyclyl group, said aryl and heterocyclyl groups being optionally substituted with a (C1-C4) alkyl group or a hydroxyl group,
• or, alternatively, R12 and R13 form, together with the nitrogen atom that bears them, a group
• —COOR14 where R14 is a (C1-C4) alkyl group,
• —NH—CO—NR15R16 where R15 and R16 are, independently of each other, hydrogen, (C1-C4) alkyl, phenyl or benzyl, said phenyl and benzyl being optionally substituted with one or more substituents selected from halogen, (C1-C4) alkyl and (C1-C4) alkoxy,
• —SO2—NR17R18 where R17 and R18 are, independently of each other, hydrogen or (C1-C4) alkyl,
• —SO2—R19 where R19 is (C1-C4) alkyl or an aryl group,
• a heterocyclyl group selected from 1,3-dioxolanyl, imidazolyl, tetrazolyl, triazolyl optionally substituted with a (C1-C4) alkyl group, thiazolyl, pyrimidyl, oxadiazolyl and pyridyl, the imidazolyl being optionally substituted on the nitrogen atom with a (C1-C4) alkyl group or a benzyl, the tetrazolyl being optionally substituted with a (C1-C4) alkyl group or a benzyl, and the oxadiazolyl being optionally substituted with a (C1-C4) alkyl, or
• —NH—CO—OR15, R15 corresponding to the above definition,
• or a salt, a hydrate or a solvate, as well as the enantiomers, diastereoisomers, rotamers, atropoisomers, including mixtures thereof.