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US 2007/0185113 A1Published application
Heteroaryl and benzyl amide compounds
AssigneeHoffmann-La Roche Inc.
InventorsChristoph Faeh, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger
Life of this patent
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Abstract
Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
Claims7
A compound of formula I
- wherein
- R1 is hydrogen, C1-C6alkyl, hydroxy or halogen;
- R2 is hydrogen, C1-C6alkyl, halogen-C1-C6alkyl, C2-C6alkenyl, heterocyclyl, unsubstituted aryl or aryl substituted by one or more substituents selected from halogen, C1-C6alkyl and halogen-C1-C6alkyl, —OR6, wherein R6 is C1-C6alkyl, halogen-C1-C6alkyl or phenyl, —NR7R8, wherein R7 and R8 independently are hydrogen, C1-C6alkyl or phenyl, or —C(O)—OR9, wherein R9 is hydrogen or C1-C6alkyl;
- R3 is unsubstituted heteroaryl or heteroaryl substituted by one or more substituents selected from halogen, C1-C6alkyl, halogen-C1-C6alkyl, C3-C8cycloalkyl and halogen-C3-C8cycloalkyl;
- R4 is a group (a)
- wherein
- A is CR17 or N, wherein R17 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
- B is CR18 or N, wherein R18 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
- D is CR19 or N, wherein R19 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy, C2-C6alkenyl or phenyl;
- E is CR20 or N, wherein R20 is hydrogen, halogen, C1-C6alkyl, C1-C6alkoxy or C2-C6alkenyl;
- R10 and R11 are independently hydrogen, halogen, C1-C6alkyl, COR wherein R is C1-C6alkyl, C1-C6alkoxy or C3-C6cycloalkyl, S(O)2—C1-C6alkyl, C3-C6cycloalkyl, or phenyl;
- or together are C1-C6alkylene;
- or, when A is CR17,
- R11 and R17 together are —CH═CH—, —CH2—CH2— or —N═CH—;
- and
- n is 1, 2 or 3;
- and all pharmaceutically acceptable salts thereof.
14 more elements
Dependencies are inferred from the claim text.