Inhibitors of protein kinases

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is R5-L1 or R6-L2;
• R2 and R are independently selected from the group consisting of hydrogen, C1-6 alkyl, halogen, hydroxyl, C1-6 alkoxy, C1-6 haloalkyl, amino, C1-6 alkylamino, and C1-6 dialkylamino, or alternatively R2 and R3 together with the carbon atoms to which they are attached form a 5-8 membered ring;
• R4 is
• wherein X1 and x2 are independently (CR7R8)n, wherein n is independently at each occurrence 1, 2, or 3, and wherein Z is —O—, —NH—, —HN—SO2—, —NHC(O)—, —S—, —S(O)—, —SO2—, or —C(O)—, or R4 is C1-6 alkoxy, C1-6 alkylamino or di(C1-6)alkylamino;
• R5 is a 5- or 6-membered aryl or heteroaryl ring containing 1, 2, 3, or 4 heteroatoms optionally substituted with one or more groups independently selected from the group consisting of halogen, alkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, amino, aminocarbonyl, C1-6 alkylaminocarbonyl, C1-6 dialkylaminocarbonyl, phenyl, and methoxyphenyl;
• L1 is a single bond, —O—, —S—, —CH2—, —OCH2—, —CH2O—, —SCH2—, —CH2S—, —CH(OH)—, —C(O)—, —CX2—, or —CXH—, wherein X is a halogen;
• R6 is morpholinyl, thiomorpholinyl, tetrahydropyranyl, tetrahydrofuranyl, oxothiomorpholinyl, dioxothiomorpholinyl, piperazinyl, or piperidinyl;
• and
• L2 is (CR9R10)m, wherein each occurrence of R9 and R10 is independently selected from the group consisting of H and C1-4 alkyl, and m is 1, 2, or 3;
• Q is a diradical of a 5-membered heteroaryl ring or a phenyl ring, each of which is optionally substituted with one or more of R11 and R12;
• G is a linker of an optionally substituted C1-3 alkylene, C═O, —C(O)NH—, or a single bond;
• R7 and R8 are independently at each occurrence hydrogen, C1-4 alkyl, halogen, hydroxyl, amino, C1-4 alkylamino, aminocarbonyl, C1-4 alkylaminocarbonyl, C1-4 alkoxycarbonyl, hydroxymethyl, aminomethyl, C1-4 alkylaminomethyl, and C1-4 alkylaminocarbonylmethyl;
• R11 is independently C3-10 alkyl or C3-10 haloalkyl, each of which is optionally substituted with one to three phenyl groups;
• C3-7 cycloalkyl, which is optionally substituted with one or more C1-3 alkyl, halogen, hydroxy, oxo, or thioketo;
• C3-10 optionally substituted cycloheteroalkyl;
• C3-10 branched alkenyl which may optionally be partially or fully halogenated, and which is optionally substituted with one to three C1-5 alkyl or a phenyl group;
• C5-7 cycloalkenyl optionally substituted with one to three C1-3 alkyl groups;
• cyano;
• or C1-4 alkoxycarbonyl;
• and
• R12 is C1-5 alkyl, halogen, hydroxy, C1-5 alkoxy, C1-5 amino, C1-5 alkylamino, C1-5 dialkylamino, or optionally substituted phenyl;
• provided that when Q is a diradical of a 5-membered heteroaryl ring, then R1 is R5-L1 wherein L1 is a single bond.