Muscarinic acetylchoine receptor antagonists

A compound according to Formula I herein below:

• wherein:
• R1 is selected from the group consisting of a substituent selected from:
• C1-6 alkanoyl, aroyl and aroylC1-6alkyl, all optionally substituted;
• R2 is selected from the group consisting of a hydrogen atom or a C1-4alkyl group;
• G is selected from the group consisting of C4-7alkyl or a group of the formula (a), (b), (c) or (d)
• Wherein,
• R3 and R4 are, independently, selected from a group consisting of a hydrogen, C1-4alkyl, aryl, or C1-2alkylaryl;
• A is selected from a group consisting of an optionally substituted C1-6alkyl
• or a group of the formula (e), (f), (g) or (h):
• wherein
• X is selected from a group consisting of a bond, NR2, O or S;
• Ar is selected from a group consisting of an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring;
• or an optionally substituted bicyclic or heterobicyclic ring system;
• Ar1 and Ar2 are, independently, selected from a group consisting of an optionally substituted phenyl ring or an optionally substituted 5- or 6-membered aromatic heterocyclic ring;
• and
• Y is selected from a group consisting of a bond, —NHCO—, —CONH—, —CH2—, or —(CH2)mY1 (CH2)n—, wherein Y1 is selected from a group consisting of O, S, SO2, or CO and m and n each represent zero or 1 such that the sum of m+n is zero or 1;
• provided that when A represents a group of formula (a), any substituent present in Ar ortho to the carboxamide moiety is necessarily a hydrogen or a methoxy group;
• r and s are, independently, selected from a group consisting of an integer from zero to 3 such that the sum of r and s is equal to an integer from 1 to 6;
• V is selected from a group consisting of a bond, O, S, —NHCO—, —CONH—, CHNHCOR3;
• and salts thereof.