Benzazepine derivatives for the treatment of neurological and psychiatric disorders

A compound of formula (I), a pharmaceutically acceptable salt, or solvate thereof:

• wherein:
• R1 represents —C3-7 cycloalkyl optionally substituted by C1-3 alkyl;
• R2 represents -aryl, -heterocyclyl, -heteroaryl, -aryl-X—C3-8 cycloalkyl, -aryl-X-aryl, -aryl-X-heteroaryl, -aryl-X-heterocyclyl, -heteroaryl-X—C3-8 cycloalkyl, -heteroaryl-X-aryl, -heteroaryl-X-heteroaryl, -heteroaryl-X-heterocyclyl, -heterocyclyl-X—C3-8 cycloalkyl, -heterocyclyl-X-aryl, -heterocyclyl-X-heteroaryl, or -heterocyclyl-X-heterocyclyl;
• X represents a bond, O, CO, —CH2O—, —COCH2—, —COCH2O—, —CONR2b—, —COCH2NR2b CO—, —CSNH—, SO2, —SO2C1-3 alkyl-, —SO2C2-3 alkenyl-, —COC2-3 alkenyl-, —CO—C(R2a)(R2b)—, or —CO—C(R2a)(R2b)CH2—;
• R2a represents hydrogen or C1-6 alkyl;
• R2b represents hydrogen, C1-6 alkyl, aryl, heteroaryl, heterocyclyl, or C1-6 alkylamido;
• R3 represents halogen, C1-6 alkyl, C1-6 alkoxy, cyano, amino, or trifluoromethyl;
• n is 0, 1, or 2;
• wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl groups of R2 may be optionally substituted by one or more substituents which may be the same or different, and which are selected from the group consisting of halogen, hydroxy, cyano, nitro, ═O, haloC1-6 alkyl, haloC1-6 alkoxy, C1-6 alkyl, hydroxyC1-6 alkyl, C1-6 alkoxy, arylC1-6 alkoxy, C1-6 alkylthio, C1-6 alkoxyC1-6 alkyl, C3-7 cycloalkylC1-6 alkoxy, C1-6 alkanoyl, C1-6 alkoxycarbonyl, C1-6 alkylsulfonyl, C1-6 alkylsulfinyl, C1-6 alkylsulfonyloxy, C1-6 alkylsulfonylC1-6 alkyl, sulfonyl, arylsulfonyl, arylsulfonyloxy, arylsulfonylC1-6 alkyl, aryloxy, C1-6 alkylsulfonamido, C1-6 alkylamino, C1-6 alkylamido, —R5, —CO2R5, —COR5, —C1-6 alkyl-COR5, C1-6 alkylsulfonamidoC1-6 alkyl, C1-6 alkylamidoC1-6 alkyl, arylsulfonamido, arylcarboxamido, arylsulfonamidoC1-6 alkyl, arylcarboxamidoC1-6 alkyl, aroyl, arylC1-6 alkyl, aroylC1-6 alkyl, arylC1-6 alkanoyl, or a group —NR6R7, —C1-6 alkyl-NR6R7, —C3-8 cycloalkyl-NR6R7, —CONR6R7, NR6COR7, —NR6SO2R7, —OCONR6R7, —NR6CO2R7, —NR5CONR6R7, and —SO2NR6R7,
• wherein said R5, R6, and R7 independently represent hydrogen, C1-6 alkyl, haloC1-6 alkyl, —C3-8 cycloalkyl, —C1-6 alkyl-C3-8 cycloalkyl, aryl, —C1-6 alkyl-aryl, heterocyclyl, or heteroaryl;
• or wherein —NR6R7 may represent a nitrogen containing heterocyclyl group, and wherein said R5, R6 and R7 groups may be optionally substituted by one or more substituents which may be the same or different, and which are selected from the group consisting of halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, cyano, amino, ═O, and trifluoromethyl.