Bicyclic heterocylces, pharmaceutical compositions containing these compounds, their use and processes for preparing them

A bicyclic heterocycle of formula

• wherein
• Ra denotes a hydrogen atom or a C1-4-alkyl group,
• Rb denotes a phenyl, benzyl or 1-phenylethyl group, wherein the phenyl nucleus in each case is substituted by the groups R1 to R3, while
• R1 and R2, which may be identical or different, in each case denote a hydrogen, fluorine, chlorine, bromine or iodine atom,
• a C1-4-alkyl, hydroxy, C1-4-alkoxy, C2-3-alkenyl or C2-3-alkynyl group,
• an aryl, aryloxy, arylmethyl or arylmethoxy group,
• a heteroaryl, heteroaryloxy, heteroarylmethyl or heteroarylmethoxy group,
• a methyl or methoxy group substituted by 1 to 3 fluorine atoms or
• cyano, nitro or amino group, and
• R3 denotes a hydrogen, fluorine, chlorine or bromine atom,
• a methyl or trifluoromethyl group,
• Rc denotes a hydrogen atom or a fluorine, chlorine or bromine atom,
• a hydroxy or C1-4-alkyloxy group,
• a methoxy group substituted by 1 to 3 fluorine atoms,
• an ethyloxy group substituted by 1 to 5 fluorine atoms,
• a C2-4-alkyloxy group which is substituted by a group R4, while
• R4 denotes a hydroxy, C1-3-alkyloxy, C3-6-cycloalkyloxy, C3-6-cycloalkyl-C1-3-alkyloxy, amino, C1-3-alkylamino, di-(C1-3-alkyl)amino, bis-(2-C1-3-alkyloxy-ethyl)-amino, bis-(3-C1-3-alkyloxy-propyl)-amino, pyrrolidin-1-yl, piperidin-1-yl, homopiperidin-1-yl, morpholin-4-yl, homomorpholin-4-yl, piperazin-1-yl, 4-(C1-3-alkyl)-piperazin-1-yl, homopiperazin-1-yl or 4-(C1-3-alkyl)-homopiperazin-1-yl group,
• a C3-7-cycloalkyloxy or C3-7-cycloalkyl-C1-4-alkyloxy group,
• a tetrahydrofuran-3-yloxy, tetrahydropyran-3-yloxy or tetrahydropyran-4-yloxy group,
• a tetrahydrofuranyl-C1-4-alkyloxy or tetrahydropyranyl-C1-4-alkyloxy group,
• a pyrrolidin-3-yloxy, piperidin-3-yloxy or piperidin-4-yloxy group,
• a 1-(C1-3-alkyl)-pyrrolidin-3-yloxy, 1-(C1-3-alkyl)-piperidin-3-yloxy or 1-(C1-3-alkyl)piperidin-4-yloxy group,
• a C1-4-alkoxy group which is substituted by a pyrrolidinyl, piperidinyl or homopiperidinyl group substituted in the 1 position by the group R5, where
• R5 denotes a hydrogen atom or a C1-3-alkyl group,
• or a C1-4-alkoxy group which is substituted by a morpholinyl or homomorpholinyl group substituted in the 4 position by the group R5, where R5 is as hereinbefore defined,
• Re and Rd, which may be identical or different, in each case denote a hydrogen atom or a C1-3-alkyl group and
• X denotes a methyne group substituted by a cyano group or a nitrogen atom,
• while by the aryl groups mentioned in the definition of the above groups is meant in each case a phenyl group which is mono- or disubstituted by R6, while the substituents may be identical or different and
• R6 denotes a hydrogen atom, a fluorine, chlorine, bromine or iodine atom or a C1-3-alkyl, hydroxy, C1-3-alkyloxy, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy or cyano group,
• by the heteroaryl groups mentioned in the definition of the above groups is meant a pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl group, while the above-mentioned heteroaryl groups are mono- or disubstituted in each case by the group R6, while the substituents may be identical or different and R6 is as hereinbefore defined, and
• unless otherwise stated, the above-mentioned alkyl groups may be straight-chain or branched,
• a tautomer or a stereoisomer thereof, or a mixture of such thereof, or a salt thereof.