Methods of treating, preventing and inhibiting cancer metastasis and tumor formation
AssigneeWashington University
InventorsKatherine Weilbaecher, Suzanne Bakewell
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Abstract
Disclosed are methods for treating, preventing or inhibiting tumor cell metastasis, tumor cell formation, and destroying tumors in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated aIIbβ3 receptor antagonist and by transplanting affected bone marrow with β3−/−marrow or controlling the expression of β3 integrin in vitro or in vivo. The activated allbβ3 receptor antagonist is preferably a spiro compound.
Claims42
A method for treating, preventing or inhibiting tumor cell metastasis in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated αllbβ3 receptor antagonist.
A method for preventing or inhibiting tumor cell formation in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated αIIbβ3 receptor antagonist.
A method for destroying a tumor in a subject comprising administering to the subject in need of such therapy a therapeutically effective amount of an activated αllbβ3 receptor antagonist.
A method for treating, preventing or inhibiting tumor cell metastasis to bone in a subject comprising replacing substantially all bone marrow affected by tumor cell metastasis transplant in the subject, wherein said bone marrow is replaced with β3−/−bone marrow.
A method for treating, preventing or reversing tumor metastasis or formation comprising modulating β3 integrin expression.
Dependencies are inferred from the claim text.