Nitrogeneous polycyclic derivatives useful as chelators of metal ions and their applications

A drug composition comprising at least one nitrogeneous polycyclic derivative of the following formula

• wherein
• m=1, 2 or 3
• Rn is anyone of R1, R2, R3 and R4, which are identical or different and represent H or represent one or several radicals and are selected in the group comprising OH, an alkyl radical, O-alkyl group, NH2, NH-alkyl, N(R5, R6), or an halogen selected in the group consisting of F, Cl, Br, the alkyl being in said radical or groups, a C1-C6 alkyl, R5 and R6 being a C1-C3 alkyl group,
• Y forms a phenyl group with both pyridines, optionally ortho-substituted by a substituent R7, or ortho-disubstituted by R7 and R8, said substituents being identical or different, and selected in the group comprising an alkyl radical, 0-alkyl group, NH2, NH-alkyl, N(R5, R6), or an halogen selected between the group consisting of F, Cl, Br, the alkyl being in said radical or groups a C1-C6 alkyl and R5 and R6 are as above defined
• or
• Y represents a group —(CH2)m1—W—(CH2)m2—, with m1 and m2 being 0, 1 or 2 and W being a group CH2, CH(R9), O, or N(R10), R9 and R10 being a C1-C3 alkyl radical, or H,
• Z is a linking arm of formula -A-(CH2)n-U-(CH2)n-A-
• wherein
• A being O or NH, and
• U being selected in the group comprising (CH2)n1, CHN(R5,R6), CHCOOH, CHOH
• with n being a number from 1 to 6, preferably from 2 to 4, and n1 being 0 or 1,
• and the complexes thereof with transition metals, particularly with copper, zinc or iron.