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US 2007/0185071 A1Published application
Histone deacetylase inhibitor and process for producing the same
AssigneeRiken
InventorsMinoru Yoshida, Norikazu Nishino
Life of this patent
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Abstract
HDAC inhibitors represented by formula (1) show strong inhibitory activity against various subtypes of HDACs. The compounds of the present invention find utility as pharmaceutical agents for treating or preventing diseases associated with HDAC 1, 4, and 6. The methods for producing the compounds of the present invention enable easy and simple synthesis of various types of these compounds, and are expected to contribute to the development of HDAC inhibitors having novel properties and the like.
Claims11
A compound represented by formula (1)
- wherein
- R11, R21, R31, and R41 independently represent a hydrogen or methyl group;
- R22, R23, R32, R33, R42, and R43 independently represent any one of hydrogen, a linear alkyl group comprising 1 to 6 carbons, a linear alkyl group comprising 1 to 6 carbons to which a non-aromatic cyclic alkyl group or a substituted or unsubstituted aromatic ring is attached, a non-aromatic cyclic alkyl group, or a non-aromatic cyclic alkyl group to which a non-aromatic cyclic alkyl group or a substituted or unsubstituted aromatic ring is attached;
- R21 and R22, R22 and R23, R31 and R32, R32 and R33, R41 and R42, and R42 and R43 may independently represent a non-cyclic structure without bonding to each other, or may independently represent a cyclic structure by bonding to each other through a linear alkylene group having a chain length of 1 to 5 carbons, a linear alkylene chain having a chain length of 1 to 5 carbons and carrying a branched chain of 1 to 6 carbon atoms, or a linear alkylene chain having a chain length of 1 to 5 carbons and carrying a cyclic structure of 1 to 6 carbon atoms;
- n can be selected from a range of numbers that enable the compound to have HDAC inhibitory activity;
- and
- X represents a structural component having a structure that can coordinate with the zinc positioned at the active center of histone deacetylase.
4 more elements
Dependencies are inferred from the claim text.