US 2007/0185059 A1 · Antiallergic agents

Abstract

A medicament for the preventive and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein X represents a connecting group whose number of atoms in the main chain is 2 to (said connecting group may be substituted), A represents hydrogen atom or acetyl group, E represents an aryl group which may be substituted or a hetero aryl group which may be substituted, ring Z represents an arene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above, or a heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A wherein A has the same meaning as that defined above and the group represented by formula —X-E wherein each of X and E has the same meaning as that defined above.

A method for the prophylactic and/or therapeutic treatment of allergic diseases and/or endometriosis and/or hysteromyoma in a mammal, which comprises administering to a mammal a prophylactically and/or therapeutically effective amount of a substance selected from the group consisting of a compound represented by the following general formula (I), a pharmacologically acceptable salt thereof, a hydrate thereof, and solvate thereof:

wherein X represents a connecting group whose number of atoms in the main chain is 2 to 5 (said connecting group may be substituted),
A represents hydrogen atom or acetyl group,
E represents an aryl group which may be substituted or a heteroaryl group which may be substituted,
ring Z represents an arene or heteroarene which may have one or more substitutents in addition to the group represented by formula —O-A or —X-E, provided that the compounds represented by the following (1) and (2) are excluded:
(1) The compounds represented by the aforementioned formula (I) wherein X is a group represented by the following formula:
wherein the bond at the left end binds to ring Z and the bond at the right end binds to E,
E is a 3,5-di-substituted phenyl group wherein at least one of said substitutents is trifluoromethyl group,
ring Z is a benzene ring which may have one or more substitutents selected from the group consisting of:
a halogen atom;
a nitro group;
a cyano group;
an alkoxy group;
an alkyl group which may be substituted with one or more substitutents selected from the group consisting of
a hydroxyl group,
an alkyl-oxy-imino group, and
an aralkyl-oxy-imino group;
an alkenyl group which may be substituted with one or more substitutents selected from the group consisting of:
an aryl group,
a cyano group,
an alkyl-oxy-carbonyl group, and
a carboxy group;
an alkynyl group which may be substituted with one or more substitutents selected from the group consisting of:
an aryl group, and
a tri(alkyl)silyl group;
a halogenated alkyl group;
an aryl group which may be substituted with one or more substitutents selected from the group consisting of:
a halogen atom, and
a halogenated alkyl group;
an aralkyl group;
a 5 to 9-membered heteroaryl group which may be substituted with one or more alkyl groups;
an alkyl-carbonyl group;
a 6-membered nonaromatic heterocyclic-carbonyl group which may be substituted with one or more aralkyl groups;
a 5-membered heteroaryl-sulfonyl group;
a carboxy group;
an alkyl-oxy-carbonyl group;
a carbamoyl group which may be substituted with one or more substitutents selected from the group consisting of:
an aryl group which may be substituted with one or more halogenated alkyl groups, and
an alkyl group;
a sulfamoyl group which may be substituted with one or more substitutents selected from the group consisting of:
an aryl group which may be substituted with one or more halogenated alkyl groups, and
an alkyl group;
an amino group which may be substituted with one or more substitutents selected from the group consisting of:
an alkyl group,
an alkyl-carbonyl group,
an aryl-carbonyl group,
an alkyl-sulfonyl group, and
an aryl-sulfonyl group;
an ureido group which may be substituted with one or more aryl groups;
a thioureido group which may be substituted with one or more aryl groups;
a diazenyl group which may be substituted with one or more aryl groups
wherein said aryl groups may be substituted with one or more substitutents selected from the group consisting of:
a nitro group, and
a 6-membered heteroaryl-sulfamoyl group;
and
a hydroxy group;
in addition to the group represented by formula —O-A and the group represented by formula —X-E, and
(2) The compounds represented by the aforementioned formula (I) wherein X is a group represented by the following formula:
wherein the bond at the left end binds to ring Z and the bond at the right end binds to E,
E is a 2,5-di-substituted phenyl group wherein at least one of said substitutents is trifluoromethyl group,
ring Z is a benzene ring which may have one or more substitutents in addition to the group represented by formula —O-A and the group represented by formula —X-E.

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Antiallergic agents

Life of this patent

Antiallergic agents

Life of this patent

Abstract

Claims11