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US 2007/0185058 A1Published application
Heteroaryl and benzyl amide compounds
AssigneeHoffman-La Roche Inc.
InventorsAurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
Life of this patent
Estimating the term…
Abstract
Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.
Claims16
A compound of formula I
- wherein
- R1 is C1-C6alkyl, halo-C1-C6alkyl, halo-C1-C6alkoxy, C3-C8cycloalkyl, halo-C3-C8cycloalkyl or tri-C1-C6alkylsilyl;
- R2 is hydrogen or a group
- wherein
- R6 and R7 are independently hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R8 and R9 are independently hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- X is CR12 or N;
- Y is CH or N;
- wherein X and Y are not N at the same time;
- R12 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R5 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R4 is hydrogen, or is C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy when at least one of R3, R5, R10 and R11 is not hydrogen;
- A is CR10 or N;
- B is CR11 or N;
- D is CR3 or N;
- wherein —B=A- and -A=D- are not —N═N—;
- R3 is hydrogen, C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy;
- R10 is hydrogen, or is C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy, when at least one of R3, R4, R5 and R1 is not hydrogen;
- R11 is hydrogen or is C1-C6alkyl, halo-C1-C6alkyl, halogen, C3-C8cycloalkyl, OH or halo-C1-C6alkoxy, when at least two of R3, R4, R5 and R10 are not hydrogen;
- wherein at least two of R3, R4, R5, R10 and R11 are not hydrogen;
- and
- n is 1, 2 or 3;
- and pharmaceutically acceptable salts thereof.
20 more elements
Dependencies are inferred from the claim text.