Modulation of ace2 expression
OwnerKenneth Dobie, Susan Freier +4inventors
InventorsKenneth Dobie, Susan Freier, Michael Buchmeier, Benjamin Neuman, C. Bennett, Namir Sioufi
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Abstract
Compounds, compositions and methods are provided for modulating the expression of ACE2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding ACE2. Methods of using these compounds for modulation of ACE2 expression and for diagnosis and treatment of diseases and conditions associated with expression of ACE2 are provided.
Claims17
1-44. (canceled)
A method of inhibiting SARS virus infection or replication in a cell or tissue, comprising contacting said cell or tissue with an antisense compound 12 to 30 nucleobases in length targeted to a nucleic acid molecule encoding ACE2 (SEQ ID NO:
- 4), wherein said compound is specifically hybridizable with said nucleic acid molecule encoding ACE2.
Dependencies are inferred from the claim text.