Back to results
US 2007/0185040 A1Published application
Guanidinium derivatives for improved cellular transport
AssigneeThe Regents of the University of California
InventorsYitzhak Tor, Nathan Luedtke
Life of this patent
Estimating the term…
Abstract
Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.
Claims32
A composition comprising a compound conjugated to an adduct of a dialkoxy substance and a guanidinylating reagent.
A method of increasing the cellular uptake of a beneficial compound, comprising:
- (a) modifying a dialkoxy substance by treating the dialokoxy compound with a guanidinylating reagent to form an adduct;
- (b) conjugating the adduct with the beneficial compound to form a conjugate;
- and
- (c) delivering the conjugate to a cell.
1 more element
Dependencies are inferred from the claim text.