Immune response suppressor and treatment of multiple sclerosis
AssigneeResearch Development Foundation
InventorStaley Brod
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of treating multiple sclerosis, type 1 diabetes mellitus and other autoimmune diseases by administering a soluble immune response suppressor (SIRS) peptide or a variant thereof to an individual having such disease. The SIRS peptide or variant reduces the severity of or frequency of relapse of multiple sclerosis and reduces the inflammation associated with multiple sclerosis and other autoimmune diseases.
Claims49
(canceled)
The method of claim 14, wherein X1 is Met, Val, Leu or Cys.
The method of claim 14, wherein X2 is Thr, Ala or Gly.
The method of claim 14, wherein X3 is Glu, Arg, Asp or Lys.
The method of claim 14, wherein X4 is Gln, Ser, Asn or Gly.
The method of claim 14, wherein X5 is Glu, Arg, Asp or Lys.
The method of claim 14, wherein X6 is Ile, Leu, Val, Met or Thr.
The method of claim 14, wherein X7 is Ala, Cys, Thr or Gly.
The method of claim 14, wherein X3 is Asp or Glu.
The method of claim 14, wherein the polypeptide comprises the sequence of SEQ ID NO:1.
A method of immunotherapy in an individual comprising orally administering-to the individual a therapeutically effective amount of a polypeptide comprising the amino acid sequence (SEQ ID NO:4):
- X1-X2-X3-X3-X4-X4-X4-X4-X4-X4-Pro-X5-X2-X2-X6-X4-X4-X7-X7-X3-X4
- wherein X1 is Met, Val, Leu or Cys;
- X2 is Thr, Ala or Gly;
- X3 is Glu, Arg, Asp or Lys;
- X4 is Gln, Ser, Asn or Gly;
- X5 is Glu, Arg, Asp or Lys;
- X6 is Ile, Leu, Val, Met or Thr, and;
- X7 is Ala, Cys, Thr or Gly.
(canceled)
23-29. (canceled)
A method for treating or preventing Type 1 diabetes or multiple sclerosis in an individual comprising administering to the individual a therapeutically effective amount of a polypeptide comprising the amino acid sequence (SEQ ID NO:4):
- X1-X2-X3-X3-X4-X4-X4-X4-X4-X4-Pro-X5-X2-X2-X6-X4-X4-X7-X7-X3-X4
- wherein X1 is Met, Val, Leu or Cys;
- X2 is Thr, Ala or Gly;
- X3 is Glu, Arg, Asp or Lys;
- X4 is Gln, Ser, Asn or Gly;
- X5 is Glu, Arg, Asp or Lys;
- X6 is Ile, Leu, Val, Met or Thr, and;
- X7 is Ala, Cys, Thr or Gly.
Dependencies are inferred from the claim text.