Antiproliferative peptides and antibodies for their detection
AssigneeBiospectrum, Inc.
InventorEytan Barnea
Life of this patent
Estimating the term…
Abstract
The present invention relates to developmental peptides and peptidomimetics thereof, which may be used therapeutically to inhibit abnormal cell proliferation of damaged cells, including cancer cells or virally infected cells. In one embodiment, a seven to eleven amino acid developmental peptide and methods of using the same is provided.
Claims61
A peptide comprising the amino acid sequence of Xaam-Gly-Lys-Arg-Ile-Xaan, wherein m independently has a value from 0 to 20 and n independently has a value from 0 to 20.
A peptide comprising the amino acid sequence Xaam-Lys-Gly-Thr-Xaan, wherein m independently has a value from 0 to 20, preferably less than 10, and wherein n independently has a value from 0 to 20.
A compound comprising the formula R1—R2—R3—R4—R5—R6—R7—OH, wherein R1 is Gly or a mimetic of Gly;
- R2 is Lys or a mimetic of Lys;
- R3 is Arg or a mimetic of Arg;
- R4 is Ile or a mimetic of Ile;
- R5 is Lys or a mimetic of Lys;
- R6 is Gly or a mimetic of Gly;
- and R7 is Thr or a mimetic of Thr.
A compound comprising the formula X—R1—R2—R3—R4—R5—R6—R7—OH, wherein X may comprise two to four amino acid residues or mimetics of said residues, R1 is Gly or a mimetic of Gly, R2 is Lys or a mimetic of Lys, R3 is Arg or a mimetic of Arg, R4 is Ile or a mimetic of Ile, R5 is Lys or a mimetic of Lys, R6 is Gly or a mimetic of Gly and R7 is Thr or a mimetic of Thr.
A method of detecting developmental peptide receptor positive cells comprising administering a developmental peptide and measuring binding of said developmental peptide.
A method of treating a proliferative disorder comprising administering a developmental protein or peptidomimetic thereof.
An antibody directed to a developmental peptide.
A method of diagnosing a proliferative disorder of a mammal comprising administering an antibody to a developmental protein.
A method of identifying abnormal cell proliferation comprising administering a developmental peptide antibody.
A method of treating a retrovirus comprising administering an antibody to a developmental protein.
A method of inhibiting reverse transcriptase comprising administering a developmental protein.
A method of treating a hypoproliferative disorder comprising administering an antibody to a developmental protein.
A compound comprising a developmental peptide or peptidomimetic thereof and an agent.
A nucleic acid comprising a sequence encoding for the peptide comprising N-Val-Leu-Gly-Lys-Arg-Ile-Lys-Gly-Thr-OH (SEQ ID No.2).
A method of identifying pregnancy related disorders comprising administering an antibody directed to a developmental peptide.
A method of screening a compound for a teratogenic or mutagenic effect comprising exposing a tissue sample to said compound, incubating said tissue sample with said compound, exposing said tissue sample to a labeled developmental peptide, and determining the presence of a developmental peptide receptor.
Dependencies are inferred from the claim text.