Novel antimicrobial peptides with heparin binding activity
AssigneeDermagen AB
InventorsArtur Schmidtchen, Martin Malmsten
Life of this patent
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Abstract
The invention relates to an antimicrobial peptide with heparin binding activity, being derived from endogenous mammalian proteins being substantially free from antimicrobial activity selected from the group consisting of laminin isoforms, complement factor C3, histidin rich glycoprotein and kininogen and having from 10 to 36 amino acid residues, wherein the antimicrobial peptide consists of at least four amino acid residues selected from the group consisting of K, R and H. The invention also relates to pharmaceutical compositions comprising said antimicrobial peptide and use of the antimicrobial peptide and/or antimicrobial/pharmaceutical composition.
Claims29
-49. (canceled)
An antimicrobial peptide with heparin binding activity, the peptide comprising a 10 to 36 amino acid residue portion of the amino acid sequence KHNLGHGHKH ERDQGHGHQR GHGLGHGHEQ QHGLGHGHKF KLDDDLEHQG GHVLDHGHKHKHGHGHGKH KNKGKKNGKH NGWK or a variant thereof, wherein at least 30% of the residues of the 10 to 36 amino acid residue portion are selected from the group consisting of K, R and H.
An antimicrobial peptide with heparin binding activity, the peptide comprising a 10 to 36 amino acid residue portion of the amino acid sequence SVQLTEKRM DKVGKYPKEL RKCCEDGMRE NPMRFSCQRR TRFISLGEAC KKVFLDCCNY ITELRRQHAR ASHLGLAR or a variant there of, wherein the 10 to 36 amino acid residue portion comprises at least four amino acids selected from the group consisting of K, R and H.
Dependencies are inferred from the claim text.