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AssigneeThe Rockefeller University
InventorsTom Muir, Patricia Mayville, Richard Novick, Ronald Beavis, Guangyong Ji
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The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
A method for treating a Staphylococcus aureus (S. aureus) infection in a subject comprising administering to the subject an amount of a cyclic peptide effective to treat the infection, said cyclic peptide comprising the structure:
A method for treating a Staphylococcus aureus (S. aureus) infection in a subject comprising administering to the subject an amount of a cyclic peptide effective to treat the infection, said cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10, wherein said cyclic peptide is administered in an effective amount to achieve a clinically significant reduction in said S. aureus infection, said method further comprising administering to the subject a therapeutically effective amount of at least one antibiotic.
Dependencies are inferred from the claim text.