Use of chk1 inhibitors to control cell proliferation
AssigneeICOS Corporation
InventorDarcey Clark
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Abstract
The present invention relates to improved methods for inhibiting aberrant cell proliferation involving the scheduling of administration of Chk1 activators (e.g., chemotherapeutic agents) and Chk1 inhibitors. At least one Chk1 activator is administered at a dose and for a time sufficient to induce substantial synchronization of cell cycle arrest in proliferating cells. Upon achieving substantial phase synchronization, at least one Chk1 inhibitor is administered to abrogate the cell cycle arrest and induce therapeutic cell death. The invention is useful with any Chk1 activator and any Chk1 inhibitor, and finds application in treating or preventing cancerous and non-cancerous aberrant cell proliferation.
Claims68
A method for controlling aberrant cell proliferation comprising
- a) contacting a cell population comprising aberrantly proliferating cells with at least one Chk1 activator in am amount sufficient to substantially synchronize cell cycle arrest among said aberrantly proliferating cells at a target phase, and
- b) upon achieving said substantial synchronization of cell cycle arrest among said aberrantly proliferating cells, contacting said cell population with a selective Chk1 inhibitor in an amount sufficient to substantially abrogate said cell cycle arrest.
Use of a composition comprising at least one Chk1 inhibitor in the manufacture of a medicament for the inhibition of aberrant cell proliferation.
Dependencies are inferred from the claim text.