Aza-quinolinol phosphonate integrase inhibitor compounds

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, and including enol and tautomeric resonance isomers;
• wherein:
• X1 is CR1, NR, or N;
• X2 is CR2, NR, or N;
• X3 is CR3, NR, or N;
• X4 is CR4, NR, or N;
• X5 is CR5, NR, or N;
• at least one of X1, X2, X3, X4, and X5 is NR or N;
• R1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from H, F, Cl, Br, I, OH, amino (—NH2), ammonium (—NH3+), alkylamino, dialkylamino, trialkylammonium, C1-C8 alkyl, C1-C8 alkylhalide, carboxylate, sulfate, sulfamate, sulfonate, 5-7 membered ring sultam, C1-C8 alkylsulfonate, C1-C8 alkylamino, 4-dialkylaminopyridinium, C1-C8 alkylhydroxyl, C1-C8 alkylthiol, alkylsulfone (—SO2R), arylsulfone (—SO2Ar), arylsulfoxide (—SOAr), arylthio (—SAr), sulfonamide (—SO2NR2), alkylsulfoxide (—SOR), formyl (—CHO), ester (—C(═O)OR), amido (—C(═O)NR2), 5-7 membered ring lactam, 5-7 membered ring lactone, nitrile (—CN), azido (—N3), nitro (—NO2), C1-C8 alkoxy (—OR), C1-C8 alkyl, C1-C8 substituted alkyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heteroaryl, and C2-C20 substituted heteroaryl, phosphonate, phosphate, polyethyleneoxy, and a prodrug moiety;
• or when X1 is CR1 and when X2 is CR2, then CR1 and CR2 together may form a ring;
• when X3 is CR3 and when X4 is CR4, then CR3 and CR4 together may form a ring;
• or when. X4 is CR4 and X5 is CR5, then CR4 and CR5 together may form a ring;
• wherein the ring is 5, 6, or 7-membered;
• R is independently selected from H, C1-C8 alkyl, C1-C8 substituted alkyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heteroaryl, and C2-C20 substituted heteroaryl;
• L is selected from a bond, O, S, NR, N—OR, C1-C12 alkylene, C1-C12 substituted alkylene, C2-C12 alkenylene, C2-C12 substituted alkenylene, C2-C12 alkynylene, C2-C12 substituted alkynylene, C(═O)NH, C(═O), S(═O)2, C(═O)NH(CH2)n, and (CH2CH2O)n, where n may be 1, 2, 3, 4, 5, or 6;
• and
• Ar is covalently attached to L and to one or more R6 and Ar is selected from C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heteroaryl, and C2-C20 substituted heteroaryl;
• where at least one of R, R2 , R3 , R4, R6, R7and R8 comprises a phosphonate group.