Artificial cartilage tissue and production method thereof
AssigneePG Research Co., Ltd.
InventorsSatoshi Miyauchi, Tatsuya Miyazaki, Satoshi Matsuzaka
Life of this patent
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Abstract
To obtain an artificial cartilage tissue having high strength and biocompatibility. There is provided an artificial cartilage tissue which is substantially free of heterologous protein and is substantially free of scaffold derived from non-cartilage-derived cells, but contains mammalian cartilage-derived cells and an extracellular matrix formed by the cartilage-derived cells, where: (1) the water retention per mg of tissue dry weight is 17.8 mg or less; (2) collagen of 5.57 μg or more per mg of tissue wet weight is contained; (3) proteoglycan of 9.22 μg or more per mg of tissue wet weight is contained.
Claims14
An artificial cartilage tissue which is substantially free of heterologous protein and is substantially free of scaffold derived from non-cartilage-derived cells, but contains mammalian cartilage-derived cells and an extracellular matrix formed by the cartilage-derived cells, and satisfies the following (1), (2), or (3):
- (1) a water retention per mg of tissue dry weight of 17.8 mg or less;
- (2) collagen of 5.57 μg or more per mg of tissue wet weight is contained;
- (3) proteoglycan of 9.22 μg or more per mg of tissue wet weight is contained.
A production method of an artificial cartilage tissue comprising;
- isolating cartilage-derived cells from a mammal;
- and culturing the isolated cartilage-derived cells under the presence of serum or plasma derived from a mammal of the same species.
Dependencies are inferred from the claim text.