Method of inducing fenestrae
OwnerDavid Shima, Sofia Ioannidouinventors
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Abstract
The present invention relates to a method of inducing fenestrae in an endothelial cell line. More particularly, the present invention relates to inducing fenestrae in a bEND5 cell line or a Py4.1 cell line utilizing latrunculin A or cytochalasin B as an inducing agent.
Claims26
A method of inducing the formation of fenestrae in an endothelial cell line selected from the group consisting of a bEND5 endothelial cell line and a Py4.1 endothelial cell line comprising the step of administering an inducing agent selected from the group consisting of latrunculin A and cytochalasin B.
A method of inducing the formation of fenestrae comprising the steps of administering latrunculin A to a bEND5 cell line.
A method of inducing the formation of fenestrae comprising the step of administering latrunculin A to a Py4.1 cell line.
A method of inducing the formation of fenestrae comprising the steps of administering cytochalasin B to a bEND5 cell line.
A method of inducing the formation of fenestrae comprising the step of administering cytochalasin B to a Py4.1 cell line.
A method of inducing the formation of fenestrae in a bEND5 cell line comprising the steps of:
- a) administering cytochalasin B to the bEND5 cell line;
- and
- b) administering VEGF-A to the bEND5 cell line.
A method of inducing the formation of fenestrae in a bEND5 cell line comprising the steps of:
- a) administering cytochalasin B to the bEND5 cell line;
- and
- b) administering PMA to the bEND5 cell line.
Dependencies are inferred from the claim text.