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US 2007/0184495 A1Published application
Rapid nasal assay kit
AssigneeToxcure, Inc.
InventorChristopher M. Shaari
Life of this patent
Estimating the term…
Abstract
The present invention relates to an assay which can be used on nasal secretions. The assay is used to determine the cause of nasal secretions, for example whether the secretions are due to an allergic reaction or a non-allergic reaction.
Claims23
A nasal secretion assay kit comprising:
- a. a nasal secretion gathering means;
- and
- b. a reagent which contains one or more substances which will react with the nasal secretion to determine whether said nasal secretion is caused by an allergic reaction or a non-allergic reaction.
A nasal secretion assay test comprising:
- a. a nasal secretion gathering means;
- and
- b. a reagent which will react with a substance selected from the group consisting of IL4, IL13, histamine, LTC4, LTD4, LTE4, eleatase, T2 lymphocytes, IgE, EG2, CCR4, CCR8 or CCR3;
- wherein a positive reaction is indicative of allergic rhinitis.
1 more element
A rapid nasal device for gathering nasal secretions for analysis comprising:
- a. an absorbant material which fits into a nasal vestibule;
- and
- b. an atomizing or aerosoling device comprising a container and a tube, wherein the tube passes through the absorbant material such that when the container is contracted, its contents pass through the tube and irrigates the nose and sinuses, and the contents are then absorbed onto the absorbant material.
A rapid nasal assay kit comprising:
- a. a nasal secretion gathering means;
- b. a capture antibody, which will react with and forms a complex with a capture substance selected from the group consisiting of TH2 cells, IL4, IL13, IL1-B, exotoxin, CCR4, CCR8, CCR3, histamine, leukocutes, EG2 and IgE;
- and
- c. a detection antibody, which will react with the complex and will generate a detectable response if the complex is present;
- wherein the presence of a detectable response indicates that a nasal secretion is the result of allergic rhinitis.
2 more elements
A rapid nasal assay kit comprising:
- a. a nasal secretion gathering means;
- b. a capture antibody, which will react with and form a complex with a capture substance selected from the group consisting of TH1 cells, INF-Gamma, CCR5 and CXCR3;
- and
- c. a detection antibody, which will react with the complex and will generate a detectable response if the complex is present;
- wherein the presence of a detectable response indicates that a nasal secretion is the result of non-allergic rhinitis.
2 more elements
A rapid nasal assay kit comprising:
- a. a nasal secretion gathering means;
- b. a first capture antibody, which will react with and form a first complex with a first capture substance selected from the group consisting of TH2 cells, IL4, IL13, IL1-B, exotoxin, CCR4. CCR8, CCR3, histamine, leukocytes, EG2 and IgE;
- and
- c. a first detection antibody, which will react with the first complex and will generate a first detectable response if the complex is present;
- d. a second capture antibody, which will react with and form a second complex with a second capture substance selected from the group consisting of TH1 cells, INF-Gamma, CCR5 and CXCR3;
- and
- e. a second detection antibody, which will react with the second complex and will generate a second detectable response if the second complex is present;
- wherein the first detectable response is distinguishable from the second detectable response;
- and
- i. a first detectable response and no second detectable response indicates that a nasal secretion is the result of allergic rhinitis;
- ii. a second detectable response and no first detectable response indicates that a nasal secretion is the result of non-allergic rhinitis;
- and
- iii. a first detectable response and a second detectable response indicates that a nasal secretion is the result of allergic rhinitis and non-allergic rhinitis.
10 more elements
Dependencies are inferred from the claim text.