Diagnosis or treatment of endothelial cell dysfunction related diseases

A method for prophylaxis or treatment of a disease or condition associated with endothelial cell dysfunction in a subject, the method comprising:

• providing a subject suffering from or thought to be at risk of suffering from a disease or condition associated with endothelial cell dysfunction;
• administering to the subject a therapeutic composition or protocol to inhibit an activity or function of profilin-1, wherein inhibiting the activity or function of profilin-1 prevents or treats the disease or condition.

A therapeutic composition for prophylaxis or treatment of a disease or condition associated with endothelial cell dysfunction in a subject, the therapeutic composition comprising:

• a inhibitor capable of inhibiting an activity or function of profilin-1;
• and
• a pharmaceutically acceptable carrier comprising the inhibitor.

A therapeutic protocol for prophylaxis or treatment of a disease or condition associated with endothelial cell dysfunction in a subject, the therapeutic protocol comprising:

• providing a subject suffering from or thought to be at risk of suffering from a disease or condition associated with endothelial cell dysfunction;
• and
• administering a small interfering RNA to the subject, wherein the small interfering RNA downregulates gene transcription associated with profilin-1 to prevent or treat the disease or condition.