Anti-abnormal type prion monoclonal antibody, process for producing the same, and immunoassay of abnormal type prion protein using the same
AssigneesObihiro University of Agriculture and Veterinary Medicine, Fujirebio Inc.
InventorsMorikazu Shinagawa, Motohiro Horiuchi, Atsushi Umetani
Life of this patent
Estimating the term…
Abstract
A monoclonal antibody which recognizes abnormal type prion protein alone is disclosed. By the present invention, an anti-abnormal type prion monoclonal antibody whose corresponding antigen is an abnormal type prion protein, and which does not substantially react with normal type prion protein was first provided. Since the corresponding antigen of the monoclonal antibody according to the present invention is the naturally occurring abnormal type prion protein, measurement of the abnormal type prion protein may be attained with high sensitivity.
Claims14
An anti-abnormal type prion monoclonal antibody whose corresponding antigen is an abnormal type prion protein, and which does not substantially react with normal type prion protein, or an antigen-binding fragment thereof.
A monoclonal antibody which undergoes antigen-antibody reaction with an abnormal type prion protein treated with proteinase K having a final concentration of 80 μg/ml, or an antigen-binding fragment thereof.
The monoclonal antibody produced by hybridoma 6H10 (FERM BP-8226), or an antigen-binding fragment thereof.
Dependencies are inferred from the claim text.