Back to results
US 2007/0184465 A1Published application
Methods for regulating hematopoiesis using CpG-oligonucleotides
AssigneeColey Pharmaceutical GmbH
InventorsHermann Wagner, Grayson Lipford
Life of this patent
Estimating the term…
Abstract
The invention relates to methods for regulating hematopoiesis using CpG containing oligonucleotides. In particular, the invention relates to methods of treating thrombopoiesis and anemia by regulating hematopoiesis. The invention also relates to methods of regulating immune system remodeling by administering CpG oligonucleotides to control hematopoiesis.
Claims21
-72. (canceled)
A composition comprising
- a CpG oligonucleotide represented by the formula 5′X1CGX2 3′ encapsulated within a cationic lipid,
- wherein X1 and X2 are nucleotides, the oligonucleotide is at least 8 nucleotides in length, and the cationic lipid is DDAB.
A method for inducing an antigen-specific immune response comprising administering to a subject
- an antigen or a nucleic acid encoding an antigen, and
- a CpG oligonucleotide having a sequence including at least
- 5′X1CGX2 3′
- in an effective amount to induce an antigen-specific immune response, wherein the oligonucleotide includes at least 8 nucleotides, X1 and X2 are nucleotides, the oligonucleotide is encapsulated within a lipid, and the oligonucleotide and the antigen are in a liposome.
1 more element
Dependencies are inferred from the claim text.