Methods of inhibiting cancer growth by binding to nuclear receptors
AssigneeImmusol, Inc.
InventorsHenry Li, Ning Ke, Mirta Grifman, Gisela Claasen, Xiuyuan Hu, Kristen Defife, Cellia Habita, Wufang Fan, Kristina Rhoades, Philip Tan, Flossie Wong-Staal
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for identifying agents useful for inhibiting cancer cells by binding to various nuclear receptor proteins, or to the genes or RNA encoding such proteins.
Claims19
A method of identifying a molecule that inhibits cancer cells, comprising:
- a. introducing said molecule into cells, wherein said molecule binds to a compound comprising SEQ ID NOS:
- 2, 1, 3, 4 or 5 or comprising the RNA correlate of SEQ ID NOS:
- 2, 1, 3, 4 or 5;
- and
- b. measuring the level of inhibition of said cells, where an increase in level indicates said molecule inhibits cancer cells.
8-9. (canceled)
A method of identifying a molecule that inhibits cancer cells, comprising:
- a. introducing said molecule into cells, wherein said molecule binds to a compound comprising an amino acid sequence selected from the group consisting of amino acid 260 to amino acid 331 of SEQ ID NO:7, amino acid 408 to amino acid 566 of SEQ ID NO:7, amino acid 264 to amino acid 335 of SEQ ID NO:6, amino acid 408 to amino acid 566 of SEQ ID NO:6, amino acid 289 to amino acid 360 of SEQ ID NO:8, amino acid 439 to amino acid 594 of SEQ ID NO:8, amino acid 53 to amino acid 124 of SEQ ID NO:9, amino acid 204 to amino acid 364 of SEQ ID NO:9, amino acid 83 to amino acid 154 of SEQ ID NO:10 and amino acid 221 to amino acid 381 of SEQ ID NO:10;
- and
- b. measuring the level of inhibition of said cells, where an increase in level indicates said molecule inhibits cancer cells.
A method of inhibiting cancer cells, comprising introducing into said cells a molecule that binds to a compound comprising SEQ ID NOS:
- 2, 1, 3, 4 or 5, or comprising the RNA correlate of SEQ ID NOS:
- 2, 1, 3, 4 or 5, whereby the level of cell inhibition is increased.
20-26. (canceled)
Dependencies are inferred from the claim text.