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US 2007/0184447 A1Published application
Chemo-centric selection of disease-related genetic profiles
AssigneeAvalon Pharmaceuticals, Inc.
InventorsJeffrey Strovel, David Bol, Paul Young
Life of this patent
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Abstract
Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.
Claims27
A method for identifying a cell susceptible to a selected chemical agent, comprising:
- (a) identifying a cell susceptible to a test compound wherein said susceptibility depends on a change in expression profile of a set of genes whose expression levels are changed in the susceptible cell due to said test compound (b) identifying a different cell from said susceptible cell wherein said different cell expresses the set of genes in the absence of treatment with test compound in (a) with the expression profile of said set of genes of said susceptible cell in the absence of treatment with a test compound, wherein said expression profile identifies said different cell as being a cell susceptible to said test compound thereby identifying said different cell as a cell susceptible to said selected chemical agent.
A method for identifying a cell susceptible to a selected chemical agent, comprising:
- (a) contacting a test compound with a cell and determining inhibition of growth of said cell due to said contacting thereby identifying said cell as a susceptible cell,
- (b) determining a change in the expression profile of a set of genes expressed by said susceptible cell wherein said change is due to said contacting thereby identifying said set of genes as an affected gene set,
- (c) determining the expression profile of said affected gene set of said susceptible cell in the absence of said contacting and thereby identifying a basal expression profile for said affected gene set,
- (d) determining said basal expression profile for said affected gene set for a different cell from said contacted cell,
- wherein said basal expression profile for said affected gene set indicates a cell susceptible to said test compound
- thereby identifying said different cell as a cell susceptible to said selected chemical agent.
3 more elements
A method for producing test data with respect to the susceptibility of a cell to a selected chemical agent, comprising:
- (a) identifying a cell susceptible to a test compound wherein said susceptibility depends on a change in expression profile of a set of genes whose expression levels are changed in the susceptible cell due to said test compound
- (b) identifying a different cell from said susceptible cell wherein said different cell expresses the set of genes in the absence of treatment with test compound with the expression profile of said set of genes of said susceptible cell in the absence of a test compound,
- (c) producing test data identifying said different cell as a cell susceptible to said selected chemical agent.
Dependencies are inferred from the claim text.