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OwnerSayoko Matsumoto, Takayoshi Mamine +2inventors
InventorsSayoko Matsumoto, Takayoshi Mamine, Masao Washizu, Osamu Kurosawa
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To verify an action of a high-frequency ac electric field on a single-stranded nucleic acid existing in an aqueous solution. This action is used to improve the efficiency of hybridization to which the single-stranded nucleic acid is subjected as a complementary strand. Provided are a method and system for stretching a single-stranded nucleic acid, which exists in a free form in pure water or an aqueous solution (R) of pH 5 to 11, or which exists in a form immobilized on one of surface (f) of an electrode (E) of opposing electrodes (E,E) arranged facing the aqueous solution (R) or in a form immobilized on surfaces (f) of both electrodes (E) of opposing electrodes (E, E), by causing a high-frequency ac electric field to act on the single-stranded nucleic acid.
A nucleic acid stretch method of stretching the following single-stranded nucleic acid (1) or (2) by causing an ac electric field of a high frequency to act on said single-stranded nucleic acid (1) or (2):
A nucleic acid stretch system provided at least with a reaction well capable of storing an aqueous solution therein and a means for forming a high-frequency ac electric field in said reaction well, characterized in that a single-stranded nucleic acid existing in said reaction well is stretched under an action of said high-frequency ac electric field.
A DNA chip characterized by use of a means for stretching a single-stranded nucleic acid, which exists in a free or immobilized form in an aqueous solution of pH 5 to 11, under an action of a high-frequency ac electric field applied to a reaction well with pure water or said aqueous solution retained therein.
Dependencies are inferred from the claim text.