Genetic markers of food allergy
OwnerGurjit Hershey, Amal Assa'ad +1inventors
InventorsGurjit Hershey, Amal Assa'ad, Ranajit Chakraborty
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Abstract
A genetic marker of food allergy is disclosed. The marker comprises variants of IL-4 receptor alpha, IL13 and CD14.
Claims21
A method to determine an individual's propensity to a food allergy comprising determining at least one of I75V, E400A, C431R, or Q576R in IL-4Rα from at least one cell in the individual wherein a single nucleotide polymorphism indicates the individual's increased propensity to a food allergen.
A method to determine an individual's propensity to a food allergy comprising determining at least one of IL-4Rα, IL-13, or a CD 14 promoter from at least one cell in the individual wherein an excess of two-locus VV (I75V at IL-4Rα)-QR (R130Q at IL-13) and QR (R130Q at IL-13)-TT (at CD14-159 C→T) indicates the individual's increased propensity to a food allergen.
A method to determine an individual's propensity to a food allergy comprising determining the presence of an allele combination comprising V75IL-4Rα/Q130IL-13/T159C→TCD14 in at least one cell in the individual wherein an increase of the allele combination over a control indicates the individual's increased propensity to a food allergen.
A method of determining an individual's propensity to a food allergy comprising analyzing at least one cell from the individual to determine a TT (CD14-159 C→T) genotype, and determining an increased propensity to a food allergy if the TT (CD14-159 C→T genotype differs from a control.
A method of determining an individual's propensity to a food allergy comprising determining in at least one cell of the individual a single nucleotide polymorphism (SNP) marker in at least one of I75V IL-4Rα, E400A IL-4Rα, C431R IL-4Rα, Q576R IL-4Rα, R130Q IL-13, or -159 C→T CD 14 compared to a control wherein the SNP marker indicates an increased propensity to a food allergy.
A method of determining an individual's propensity to a food allergy comprising determining in at least one cell of the individual a single nucleotide polymorphism (SNP) marker in -159 C→T CD 14 compared to a control wherein the SNP marker indicates an increased propensity to a food allergy.
A method of enhancing determination of an individual's propensity to a food allergy comprising analyzing at least one cell of the individual for a variant in at least a two-locus analysis to enhance association between the genotype in the individual and the phenotype of a food allergy in the individual.
A genetic marker for a food allergy comprising a single nucleotide polymorphism (SNP) in at least two of a V75 allele of a IL-4Rα gene, a Q130 allele of a IL-13 gene, and a T allele of a CD14 promoter.
A genetic marker for a food allergy consisting essentially of a -159 C→T polymorphism in a CD14 promoter.
Dependencies are inferred from the claim text.