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US 2007/0184429 A1Published application
Method for measuring aromatase activity
AssigneeGe Healthcare Limited
InventorsJohn Whateley, Rahman Ismail, Peter Laughton
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds useful for measuring aromatase activity. The invention further provides methods for measuring aromatase activity and for screening test agents which modulate aromatase activity. A kit is also provided for use in such screening methods.
Claims26
A compound comprising Formula I:
- R—L—S (I)
- wherein R is a fluorescent dye molecule;
- L is an optional linkage group containing one or more atoms
- comprising hydrocarbon chains which may also contain other atoms
- such as N, O and S;
- and
- S is molecule comprising a substrate group of the enzyme aromatase and further wherein the fluorescence signal of said compound changes in respect of fluorescence lifetime when the compound is acted upon by an enzyme with aromatase activity.
4 more elements
(canceled)
Dependencies are inferred from the claim text.