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US 2007/0184299 A1Published application
Ceramic coating and method of preparation thereof
AssigneeUniversity of Connecticut
InventorsMei Wei, Haibo Qu, Xiaohua Yu
Life of this patent
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Abstract
A ceramic coating with gradient density/porosity and/or incorporated biologically active agents can be fabricated on the surface of substrates, including the surface of implantable medical devices.
Claims29
A method of coating a substrate with a gradient ceramic coating, comprising:
- exposing a portion of a substrate to an aqueous system at a temperature of about 20° C. to about 100° C. to form a gradient ceramic coating on a surface of the substrate;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl−, SO42−, HPO42−, HCO3− and a buffer system;
- and
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5.
1 more element
A coated substrate, comprising:
- a gradient ceramic coating, wherein the gradient ceramic coating is prepared by exposing a portion of a substrate to an aqueous system, wherein the exposing is performed at a temperature of about 20° C. to about 100° C.;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl−, SO42−, HPO42−, HCO3− and a buffer system;
- and
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5.
1 more element
A method of incorporating a biologically active agent into a ceramic coating on a substrate, comprising:
- exposing a portion of a substrate to an aqueous system at a temperature of about 20° C. to about 100° C. to form a ceramic coating on a surface of the substrate;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl−, SO42−, HPO42−, HCO3−, a buffer system, and a biologically active agent;
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5;
- wherein the ratio of aqueous system volume to the substrate surface area is about 5 to about 50;
- and
- wherein the biologically active agent concentration in the aqueous system is less than about 1 mg/ml.
3 more elements
A coated substrate, comprising:
- a ceramic coating comprising a biologically active agent, wherein the ceramic coating is prepared by exposing a portion of a substrate to an aqueous system, wherein the exposing is performed at a temperature of about 20° C. to about 100° C.;
- wherein the aqueous system comprises water, Ca2+, Mg2+, Na+, K+, Cl−, SO42−, HPO42−, HCO3−, a buffer system and a biologically active agent;
- and
- wherein the aqueous system has an initial pH of about 5.5 to about 7.5.
1 more element
A reactor for coating a substrate with a bioactive ceramic coating, comprising:
- a liquid-holding container with a volume sufficient to allow a ratio of the aqueous system volume to the substrate surface area to be about 5 to about 50;
- and
- a gas valve to control the rate of release of a gas from the container.
Dependencies are inferred from the claim text.