Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates
AssigneePharmaceutics International, Inc.
InventorsEmadeldin Hassan, Sridhar Gumudavelli, David Goldman
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Abstract
The invention provides a composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, as well as methods of producing such a composition.
Claims38
A composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt.
The composition of claim 15, equivalent to about 200 mg to about 400 mg ibuprofen per capsule.
A method of manufacturing a solid ibuprofen concentrate, wherein at least 90% of the weight of the ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, comprising:
- (a) mixing an ibuprofen free acid with a first alkaline substance to form a first composition,
- (b) mixing the first composition with a second alkaline substance to form a second composition, and
- (c) drying the second composition to produce a solid ibuprofen concentrate.
A composition comprising a solid ibuprofen concentrate, wherein the solid ibuprofen concentrate comprises (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and wherein at least 90% of the weight of the solid ibuprofen concentrate is ibuprofen free acid and ibuprofen alkali salt, wherein the ibuprofen alkali salt is produced from a solid ibuprofen free acid using at least two alkaline substances.
Dependencies are inferred from the claim text.