US 2007/0184096 A1 · Stable Therapeutic Formulations

Abstract

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

Claims43

Dependent claims

A method for manufacturing a transdermal delivery device;

wherein the method comprises the following steps:
(i) providing a microprojection member having a plurality of microprojections;
(ii) providing a biocompatible coating formulation comprising a biologically active agent,
(iii) coating the microprojection member with the biocompatible coating formulation to form said transdermal delivery device;
and
(iv) packaging said transdermal delivery device under dry inert atmospheric conditions and/or a partial vacuum.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

11/617,639Filed 28 Dec 2006

Priority

28 Dec 2005

Published

9 Aug 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 9/0021
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/703
Transdermal patches and similar drug-containing composite devices, e.g. cataplasms: characterised by shape or structure; Details concerning…
A61K 31/716
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers,…:…
A61K 38/2242
Hormones: atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin

Stable Therapeutic Formulations

Life of this patent

Stable Therapeutic Formulations

Life of this patent

Abstract

Claims43